Hoffmann T - Search Results

1

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

Engel M, Hoffmann T, Manhart S, Heiser U, Chambre S, Huber R, Demuth HU, Bode W. Engel M, et al. Among authors: hoffmann t. J Mol Biol. 2006 Jan 27;355(4):768-83. doi: 10.1016/j.jmb.2005.11.014. Epub 2005 Nov 22. J Mol Biol. 2006. PMID: 16330047

2

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.

Engel M, Hoffmann T, Wagner L, Wermann M, Heiser U, Kiefersauer R, Huber R, Bode W, Demuth HU, Brandstetter H. Engel M, et al. Among authors: hoffmann t. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5063-8. doi: 10.1073/pnas.0230620100. Epub 2003 Apr 10. Proc Natl Acad Sci U S A. 2003. PMID: 12690074 Free PMC article.

3

The specificity of DP IV for natural substrates is peptide structure determined.

Kühn-Wache K, Hoffmann T, Manhart S, Brandt W, Demuth HU. Kühn-Wache K, et al. Among authors: hoffmann t. Adv Exp Med Biol. 2003;524:57-63. doi: 10.1007/0-306-47920-6_6. Adv Exp Med Biol. 2003. PMID: 12675223 No abstract available.

4

Investigation of DP IV-dependent protein-protein interactions using surface plasmon resonance.

Stork J, Hoffmann T, Demuth HU. Stork J, et al. Among authors: hoffmann t. Adv Exp Med Biol. 2003;524:115-9. doi: 10.1007/0-306-47920-6_15. Adv Exp Med Biol. 2003. PMID: 12675231 No abstract available.

5

Acylated hydroxamates as selective and highly potent inhibitors of dipeptidyl peptidase I.

Niestroj AJ, Schlenzig D, Heiser U, Kühn-Wache K, Cigic B, Werman M, Hoffmann T, Gerhartz B, Demuth HU. Niestroj AJ, et al. Among authors: hoffmann t. Adv Exp Med Biol. 2003;524:339-43. doi: 10.1007/0-306-47920-6_40. Adv Exp Med Biol. 2003. PMID: 12675256 No abstract available.

6

Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme.

Bär J, Weber A, Hoffmann T, Stork J, Wermann M, Wagner L, Aust S, Gerhartz B, Demuth HU. Bär J, et al. Among authors: hoffmann t. Biol Chem. 2003 Dec;384(12):1553-63. doi: 10.1515/BC.2003.172. Biol Chem. 2003. PMID: 14719797

7

Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR.

Wagner L, Hoffmann T, Rahfeld JU, Demuth HU. Wagner L, et al. Among authors: hoffmann t. Adv Exp Med Biol. 2006;575:109-16. doi: 10.1007/0-387-32824-6_12. Adv Exp Med Biol. 2006. PMID: 16700514 No abstract available.

8

Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism.

Xu Y, Nakajima Y, Ito K, Zheng H, Oyama H, Heiser U, Hoffmann T, Gärtner UT, Demuth HU, Yoshimoto T. Xu Y, et al. Among authors: hoffmann t. J Mol Biol. 2008 Jan 18;375(3):708-19. doi: 10.1016/j.jmb.2007.09.077. Epub 2007 Oct 3. J Mol Biol. 2008. PMID: 18042490 Free article.

9

Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site.

Kühn-Wache K, Bär JW, Hoffmann T, Wolf R, Rahfeld JU, Demuth HU. Kühn-Wache K, et al. Among authors: hoffmann t. Biol Chem. 2011 Mar;392(3):223-31. doi: 10.1515/BC.2011.028. Epub 2011 Feb 2. Biol Chem. 2011. PMID: 21284559

10

Highlight: dipeptidyl peptidase 4 and related proteins.

Hoffmann T, Demuth HU. Hoffmann T, et al. Biol Chem. 2011 Mar;392(3):151-2. doi: 10.1515/BC.2011.032. Biol Chem. 2011. PMID: 21291349 No abstract available.

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