O'Connor MJ - Search Results

1

hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.

Moumen A, Masterson P, O'Connor MJ, Jackson SP. Moumen A, et al. Cell. 2005 Dec 16;123(6):1065-78. doi: 10.1016/j.cell.2005.09.032. Cell. 2005. Retraction in: Cell. 2024 Oct 31;187(22):6413. doi: 10.1016/j.cell.2024.10.008 PMID: 16360036 Free article. Retracted.

2

Suppression of retroviral infection by the RAD52 DNA repair protein.

Lau A, Kanaar R, Jackson SP, O'Connor MJ. Lau A, et al. EMBO J. 2004 Aug 18;23(16):3421-9. doi: 10.1038/sj.emboj.7600348. Epub 2004 Aug 5. EMBO J. 2004. PMID: 15297876 Free PMC article.

3

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.

Lau A, Swinbank KM, Ahmed PS, Taylor DL, Jackson SP, Smith GC, O'Connor MJ. Lau A, et al. Nat Cell Biol. 2005 May;7(5):493-500. doi: 10.1038/ncb1250. Epub 2005 Apr 17. Nat Cell Biol. 2005. PMID: 15834407

4

Targeting the DNA Damage Response in Cancer.

O'Connor MJ. O'Connor MJ. Mol Cell. 2015 Nov 19;60(4):547-60. doi: 10.1016/j.molcel.2015.10.040. Mol Cell. 2015. PMID: 26590714 Free article. Review.

5

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP. Dev H, et al. Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18. Nat Cell Biol. 2018. PMID: 30022119 Free PMC article.

6

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.

Lloyd RL, Urban V, Muñoz-Martínez F, Ayestaran I, Thomas JC, de Renty C, O'Connor MJ, Forment JV, Galanty Y, Jackson SP. Lloyd RL, et al. Nucleic Acids Res. 2021 Sep 7;49(15):8665-8683. doi: 10.1093/nar/gkab628. Nucleic Acids Res. 2021. PMID: 34329458 Free PMC article.

7

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.

Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, Bouchal J, Lenobel R, Bartkova J, Lau A, O'Connor MJ, Lukas J, Bartek J. Oplustilova L, et al. Cell Cycle. 2012 Oct 15;11(20):3837-50. doi: 10.4161/cc.22026. Epub 2012 Sep 14. Cell Cycle. 2012. PMID: 22983061 Free PMC article.

8

BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.

Sun C, Yin J, Fang Y, Chen J, Jeong KJ, Chen X, Vellano CP, Ju Z, Zhao W, Zhang D, Lu Y, Meric-Bernstam F, Yap TA, Hattersley M, O'Connor MJ, Chen H, Fawell S, Lin SY, Peng G, Mills GB. Sun C, et al. Cancer Cell. 2018 Mar 12;33(3):401-416.e8. doi: 10.1016/j.ccell.2018.01.019. Cancer Cell. 2018. PMID: 29533782 Free PMC article.

9

Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response.

Min A, Jang H, Kim S, Lee KH, Kim DK, Suh KJ, Yang Y, Elvin P, O'Connor MJ, Im SA. Min A, et al. Mol Cancer Ther. 2018 Dec;17(12):2507-2518. doi: 10.1158/1535-7163.MCT-18-0234. Epub 2018 Sep 19. Mol Cancer Ther. 2018. PMID: 30232143

10

Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.

Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB. Fang Y, et al. Cancer Cell. 2019 Jun 10;35(6):851-867.e7. doi: 10.1016/j.ccell.2019.05.001. Cancer Cell. 2019. PMID: 31185210 Free PMC article.

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