Farrell NP - Search Results

1

Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge.

Harris AL, Yang X, Hegmans A, Povirk L, Ryan JJ, Kelland L, Farrell NP. Harris AL, et al. Among authors: farrell np. Inorg Chem. 2005 Dec 26;44(26):9598-600. doi: 10.1021/ic051390z. Inorg Chem. 2005. PMID: 16363817

2

Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action.

Farrell N, Kelland LR, Roberts JD, Van Beusichem M. Farrell N, et al. Cancer Res. 1992 Sep 15;52(18):5065-72. Cancer Res. 1992. PMID: 1516063

3

Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes.

Farrell N, Qu Y, Hacker MP. Farrell N, et al. J Med Chem. 1990 Aug;33(8):2179-84. doi: 10.1021/jm00170a021. J Med Chem. 1990. PMID: 2374143

4

Effects of geometric isomerism and ligand substitution in bifunctional dinuclear platinum complexes on binding properties and conformational changes in DNA.

Farrell N, Appleton TG, Qu Y, Roberts JD, Fontes AP, Skov KA, Wu P, Zou Y. Farrell N, et al. Biochemistry. 1995 Nov 28;34(47):15480-6. doi: 10.1021/bi00047a013. Biochemistry. 1995. PMID: 7492537

5

Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug.

Kloster MB, Hannis JC, Muddiman DC, Farrell N. Kloster MB, et al. Biochemistry. 1999 Nov 9;38(45):14731-7. doi: 10.1021/bi991202e. Biochemistry. 1999. PMID: 10555954

6

Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes.

McGregor TD, Balcarová Z, Qu Y, Tran MC, Zaludová R, Brabec V, Farrell N. McGregor TD, et al. J Inorg Biochem. 1999 Oct;77(1-2):43-6. doi: 10.1016/s0162-0134(99)00136-1. J Inorg Biochem. 1999. PMID: 10626352

7

Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines.

Roberts JD, Peroutka J, Beggiolin G, Manzotti C, Piazzoni L, Farrell N. Roberts JD, et al. J Inorg Biochem. 1999 Oct;77(1-2):47-50. doi: 10.1016/s0162-0134(99)00137-3. J Inorg Biochem. 1999. PMID: 10626353

8

Cellular pharmacology of polynuclear platinum anti-cancer agents.

Roberts JD, Peroutka J, Farrell N. Roberts JD, et al. J Inorg Biochem. 1999 Oct;77(1-2):51-7. doi: 10.1016/s0162-0134(99)00147-6. J Inorg Biochem. 1999. PMID: 10626354

9

Kinetics and mechanism for reduction of anticancer-active tetrachloroam(m)ine platinum(IV) compounds by glutathione.

Lemma K, Berglund J, Farrell N, Elding LI. Lemma K, et al. J Biol Inorg Chem. 2000 Jun;5(3):300-6. doi: 10.1007/pl00010658. J Biol Inorg Chem. 2000. PMID: 10907740

10

BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin.

Manzotti C, Pratesi G, Menta E, Di Domenico R, Cavalletti E, Fiebig HH, Kelland LR, Farrell N, Polizzi D, Supino R, Pezzoni G, Zunino F. Manzotti C, et al. Clin Cancer Res. 2000 Jul;6(7):2626-34. Clin Cancer Res. 2000. PMID: 10914703

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