Keefer LK - Search Results

1

Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.

Miranda KM, Katori T, Torres de Holding CL, Thomas L, Ridnour LA, McLendon WJ, Cologna SM, Dutton AS, Champion HC, Mancardi D, Tocchetti CG, Saavedra JE, Keefer LK, Houk KN, Fukuto JM, Kass DA, Paolocci N, Wink DA. Miranda KM, et al. Among authors: keefer lk. J Med Chem. 2005 Dec 29;48(26):8220-8. doi: 10.1021/jm050151i. J Med Chem. 2005. PMID: 16366603

2

HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH.

Salmon DJ, Torres de Holding CL, Thomas L, Peterson KV, Goodman GP, Saavedra JE, Srinivasan A, Davies KM, Keefer LK, Miranda KM. Salmon DJ, et al. Among authors: keefer lk. Inorg Chem. 2011 Apr 18;50(8):3262-70. doi: 10.1021/ic101736e. Epub 2011 Mar 15. Inorg Chem. 2011. PMID: 21405089 Free PMC article.

3

Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates.

Bharadwaj G, Benini PG, Basudhar D, Ramos-Colon CN, Johnson GM, Larriva MM, Keefer LK, Andrei D, Miranda KM. Bharadwaj G, et al. Among authors: keefer lk. Nitric Oxide. 2014 Nov 15;42:70-8. doi: 10.1016/j.niox.2014.08.013. Epub 2014 Sep 2. Nitric Oxide. 2014. PMID: 25192820 Free PMC article.

4

Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.

Chakrapani H, Wilde TC, Citro ML, Goodblatt MM, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: keefer lk. Bioorg Med Chem. 2008 Mar 1;16(5):2657-64. doi: 10.1016/j.bmc.2007.11.035. Epub 2007 Nov 17. Bioorg Med Chem. 2008. PMID: 18060792 Free PMC article.

5

Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.

Chakrapani H, Kalathur RC, Maciag AE, Citro ML, Ji X, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: keefer lk. Bioorg Med Chem. 2008 Nov 15;16(22):9764-71. doi: 10.1016/j.bmc.2008.09.063. Epub 2008 Sep 30. Bioorg Med Chem. 2008. PMID: 18930407 Free PMC article.

6

Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities.

Andrei D, Maciag AE, Chakrapani H, Citro ML, Keefer LK, Saavedra JE. Andrei D, et al. Among authors: keefer lk. J Med Chem. 2008 Dec 25;51(24):7944-52. doi: 10.1021/jm800831y. J Med Chem. 2008. PMID: 19053760 Free PMC article.

7

Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.

Andrei D, Salmon DJ, Donzelli S, Wahab A, Klose JR, Citro ML, Saavedra JE, Wink DA, Miranda KM, Keefer LK. Andrei D, et al. Among authors: keefer lk. J Am Chem Soc. 2010 Nov 24;132(46):16526-32. doi: 10.1021/ja106552p. Epub 2010 Oct 29. J Am Chem Soc. 2010. PMID: 21033665 Free PMC article.

8

Diazeniumdiolated carbamates: a novel class of nitric oxide donors.

Nandurdikar RS, Maciag AE, Cao Z, Keefer LK, Saavedra JE. Nandurdikar RS, et al. Among authors: keefer lk. Bioorg Med Chem. 2012 Mar 15;20(6):2025-9. doi: 10.1016/j.bmc.2012.01.046. Epub 2012 Feb 4. Bioorg Med Chem. 2012. PMID: 22356735 Free PMC article.

9

Chemistry of the diazeniumdiolates. 2. Kinetics and mechanism of dissociation to nitric oxide in aqueous solution.

Davies KM, Wink DA, Saavedra JE, Keefer LK. Davies KM, et al. Among authors: keefer lk. J Am Chem Soc. 2001 Jun 13;123(23):5473-81. doi: 10.1021/ja002899q. J Am Chem Soc. 2001. PMID: 11389629

10

Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.

Maragos CM, Morley D, Wink DA, Dunams TM, Saavedra JE, Hoffman A, Bove AA, Isaac L, Hrabie JA, Keefer LK. Maragos CM, et al. Among authors: keefer lk. J Med Chem. 1991 Nov;34(11):3242-7. doi: 10.1021/jm00115a013. J Med Chem. 1991. PMID: 1956043

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