Uno S - Search Results

1

Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.

Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW. Uno S, et al. Mol Pharmacol. 2006 Apr;69(4):1103-14. doi: 10.1124/mol.105.021501. Epub 2005 Dec 23. Mol Pharmacol. 2006. PMID: 16377763

2

Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.

Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG, Miller ML, Shertzer HG, Nebert DW. Uno S, et al. Toxicol Appl Pharmacol. 2004 May 1;196(3):410-21. doi: 10.1016/j.taap.2004.01.014. Toxicol Appl Pharmacol. 2004. PMID: 15094312

3

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.

Uno S, Dalton TP, Derkenne S, Curran CP, Miller ML, Shertzer HG, Nebert DW. Uno S, et al. Mol Pharmacol. 2004 May;65(5):1225-37. doi: 10.1124/mol.65.5.1225. Mol Pharmacol. 2004. PMID: 15102951

4

Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line.

Dragin N, Uno S, Wang B, Dalton TP, Nebert DW. Dragin N, et al. Among authors: uno s. Biochem Biophys Res Commun. 2007 Aug 3;359(3):635-42. doi: 10.1016/j.bbrc.2007.05.202. Epub 2007 Jun 6. Biochem Biophys Res Commun. 2007. PMID: 17560947 Free PMC article.

5

Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract.

Uno S, Dragin N, Miller ML, Dalton TP, Gonzalez FJ, Nebert DW. Uno S, et al. Free Radic Biol Med. 2008 Feb 15;44(4):570-83. doi: 10.1016/j.freeradbiomed.2007.10.044. Epub 2007 Nov 12. Free Radic Biol Med. 2008. PMID: 17997381 Free PMC article.

6

Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.

Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW. Dong H, et al. Among authors: uno s. Mol Pharmacol. 2009 Mar;75(3):555-67. doi: 10.1124/mol.108.051888. Epub 2008 Dec 1. Mol Pharmacol. 2009. PMID: 19047483 Free PMC article.

7

Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.

Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW. Shi Z, et al. Among authors: uno s. Int J Cancer. 2010 Nov 15;127(10):2334-50. doi: 10.1002/ijc.25222. Int J Cancer. 2010. PMID: 20127859 Free PMC article.

8

Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.

Nebert DW, Shi Z, Gálvez-Peralta M, Uno S, Dragin N. Nebert DW, et al. Among authors: uno s. Mol Pharmacol. 2013 Sep;84(3):304-13. doi: 10.1124/mol.113.086637. Epub 2013 Jun 12. Mol Pharmacol. 2013. PMID: 23761301 Free PMC article. Review.

9

Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta.

Uno S, Sakurai K, Nebert DW, Makishima M. Uno S, et al. Toxicology. 2014 Feb 28;316:34-42. doi: 10.1016/j.tox.2013.12.005. Epub 2014 Jan 3. Toxicology. 2014. PMID: 24394547

10

Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.

Uno S, Nebert DW, Makishima M. Uno S, et al. Food Chem Toxicol. 2018 Mar;113:73-82. doi: 10.1016/j.fct.2018.01.029. Epub 2018 Jan 31. Food Chem Toxicol. 2018. PMID: 29366871 Free PMC article.

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