Xie L - Search Results

1

The RCSB PDB information portal for structural genomics.

Kouranov A, Xie L, de la Cruz J, Chen L, Westbrook J, Bourne PE, Berman HM. Kouranov A, et al. Among authors: xie l. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D302-5. doi: 10.1093/nar/gkj120. Nucleic Acids Res. 2006. PMID: 16381872 Free PMC article.

2

Functional coverage of the human genome by existing structures, structural genomics targets, and homology models.

Xie L, Bourne PE. Xie L, et al. PLoS Comput Biol. 2005 Aug;1(3):e31. doi: 10.1371/journal.pcbi.0010031. Epub 2005 Aug 19. PLoS Comput Biol. 2005. PMID: 16118666 Free PMC article.

3

A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sites.

Xie L, Bourne PE. Xie L, et al. BMC Bioinformatics. 2007 May 22;8 Suppl 4(Suppl 4):S9. doi: 10.1186/1471-2105-8-S4-S9. BMC Bioinformatics. 2007. PMID: 17570152 Free PMC article.

4

In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators.

Xie L, Wang J, Bourne PE. Xie L, et al. PLoS Comput Biol. 2007 Nov;3(11):e217. doi: 10.1371/journal.pcbi.0030217. Epub 2007 Sep 26. PLoS Comput Biol. 2007. PMID: 18052534 Free PMC article.

5

Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments.

Xie L, Bourne PE. Xie L, et al. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5441-6. doi: 10.1073/pnas.0704422105. Epub 2008 Apr 2. Proc Natl Acad Sci U S A. 2008. PMID: 18385384 Free PMC article.

6

Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors.

Xie L, Li J, Xie L, Bourne PE. Xie L, et al. PLoS Comput Biol. 2009 May;5(5):e1000387. doi: 10.1371/journal.pcbi.1000387. Epub 2009 May 15. PLoS Comput Biol. 2009. PMID: 19436720 Free PMC article.

7

A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery.

Xie L, Xie L, Bourne PE. Xie L, et al. Bioinformatics. 2009 Jun 15;25(12):i305-12. doi: 10.1093/bioinformatics/btp220. Bioinformatics. 2009. PMID: 19478004 Free PMC article.

8

Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

Kinnings SL, Liu N, Buchmeier N, Tonge PJ, Xie L, Bourne PE. Kinnings SL, et al. Among authors: xie l. PLoS Comput Biol. 2009 Jul;5(7):e1000423. doi: 10.1371/journal.pcbi.1000423. Epub 2009 Jul 3. PLoS Comput Biol. 2009. PMID: 19578428 Free PMC article.

9

A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.

Durrant JD, Amaro RE, Xie L, Urbaniak MD, Ferguson MA, Haapalainen A, Chen Z, Di Guilmi AM, Wunder F, Bourne PE, McCammon JA. Durrant JD, et al. Among authors: xie l. PLoS Comput Biol. 2010 Jan 22;6(1):e1000648. doi: 10.1371/journal.pcbi.1000648. PLoS Comput Biol. 2010. PMID: 20098496 Free PMC article.

10

SMAP-WS: a parallel web service for structural proteome-wide ligand-binding site comparison.

Ren J, Xie L, Li WW, Bourne PE. Ren J, et al. Among authors: xie l. Nucleic Acids Res. 2010 Jul;38(Web Server issue):W441-4. doi: 10.1093/nar/gkq400. Epub 2010 May 19. Nucleic Acids Res. 2010. PMID: 20484373 Free PMC article.

Subsequently a sequence order independent profile-profile alignment (SOIPPA) algorithm is used to detect and align similar pockets thereby finding protein functional and evolutionary relationships across fold space [Xie, L. and Bourne, P.E. (2008) Detecting evolutio …

Subsequently a sequence order independent profile-profile alignment (SOIPPA) algorithm is used to detect and align similar pockets thereby f …

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