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Safety of direct administration of AAV2(CU)hCLN2, a candidate treatment for the central nervous system manifestations of late infantile neuronal ceroid lipofuscinosis, to the brain of rats and nonhuman primates.
Hackett NR, Redmond DE, Sondhi D, Giannaris EL, Vassallo E, Stratton J, Qiu J, Kaminsky SM, Lesser ML, Fisch GS, Rouselle SD, Crystal RG. Hackett NR, et al. Among authors: giannaris el. Hum Gene Ther. 2005 Dec;16(12):1484-503. doi: 10.1089/hum.2005.16.1484. Hum Gene Ther. 2005. PMID: 16390279
AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL.
Sondhi D, Peterson DA, Giannaris EL, Sanders CT, Mendez BS, De B, Rostkowski AB, Blanchard B, Bjugstad K, Sladek JR Jr, Redmond DE Jr, Leopold PL, Kaminsky SM, Hackett NR, Crystal RG. Sondhi D, et al. Among authors: giannaris el. Gene Ther. 2005 Nov;12(22):1618-32. doi: 10.1038/sj.gt.3302549. Gene Ther. 2005. PMID: 16052206
Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry.
Estrada LI, Robinson AA, Amaral AC, Giannaris EL, Heyworth NC, Mortazavi F, Ngwenya LB, Roberts DE, Cabral HJ, Killiany RJ, Rosene DL. Estrada LI, et al. Among authors: giannaris el. J Histochem Cytochem. 2017 Mar;65(3):153-171. doi: 10.1369/0022155416686934. Epub 2017 Jan 12. J Histochem Cytochem. 2017. PMID: 28080173 Free PMC article.
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