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Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
Kim P, Zhang YM, Shenoy G, Nguyen QA, Boshoff HI, Manjunatha UH, Goodwin MB, Lonsdale J, Price AC, Miller DJ, Duncan K, White SW, Rock CO, Barry CE 3rd, Dowd CS. Kim P, et al. Among authors: white sw. J Med Chem. 2006 Jan 12;49(1):159-71. doi: 10.1021/jm050825p. J Med Chem. 2006. PMID: 16392800 Free PMC article.
Inhibiting bacterial fatty acid synthesis.
Zhang YM, White SW, Rock CO. Zhang YM, et al. Among authors: white sw. J Biol Chem. 2006 Jun 30;281(26):17541-4. doi: 10.1074/jbc.R600004200. Epub 2006 Apr 28. J Biol Chem. 2006. PMID: 16648134 Free article. Review.
427 results