Whitty A - Search Results

1

N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model.

Baker DP, Lin EY, Lin K, Pellegrini M, Petter RC, Chen LL, Arduini RM, Brickelmaier M, Wen D, Hess DM, Chen L, Grant D, Whitty A, Gill A, Lindner DJ, Pepinsky RB. Baker DP, et al. Among authors: whitty a. Bioconjug Chem. 2006 Jan-Feb;17(1):179-88. doi: 10.1021/bc050237q. Bioconjug Chem. 2006. PMID: 16417267

2

Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta).

Runkel L, Meier W, Pepinsky RB, Karpusas M, Whitty A, Kimball K, Brickelmaier M, Muldowney C, Jones W, Goelz SE. Runkel L, et al. Among authors: whitty a. Pharm Res. 1998 Apr;15(4):641-9. doi: 10.1023/a:1011974512425. Pharm Res. 1998. PMID: 9587963

3

Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand.

Chen LL, Whitty A, Lobb RR, Adams SP, Pepinsky RB. Chen LL, et al. Among authors: whitty a. J Biol Chem. 1999 May 7;274(19):13167-75. doi: 10.1074/jbc.274.19.13167. J Biol Chem. 1999. PMID: 10224072 Free article.

4

Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium.

Chen LL, Whitty A, Scott D, Lee WC, Cornebise M, Adams SP, Petter RC, Lobb RR, Pepinsky RB. Chen LL, et al. Among authors: whitty a. J Biol Chem. 2001 Sep 28;276(39):36520-9. doi: 10.1074/jbc.M106216200. Epub 2001 Jul 25. J Biol Chem. 2001. PMID: 11473127 Free article.

5

Enhanced potency of human Sonic hedgehog by hydrophobic modification.

Taylor FR, Wen D, Garber EA, Carmillo AN, Baker DP, Arduini RM, Williams KP, Weinreb PH, Rayhorn P, Hronowski X, Whitty A, Day ES, Boriack-Sjodin A, Shapiro RI, Galdes A, Pepinsky RB. Taylor FR, et al. Among authors: whitty a. Biochemistry. 2001 Apr 10;40(14):4359-71. doi: 10.1021/bi002487u. Biochemistry. 2001. PMID: 11284692

6

Comparison of gene expression patterns induced by treatment of human umbilical vein endothelial cells with IFN-alpha 2b vs. IFN-beta 1a: understanding the functional relationship between distinct type I interferons that act through a common receptor.

da Silva AJ, Brickelmaier M, Majeau GR, Lukashin AV, Peyman J, Whitty A, Hochman PS. da Silva AJ, et al. Among authors: whitty a. J Interferon Cytokine Res. 2002 Feb;22(2):173-88. doi: 10.1089/107999002753536149. J Interferon Cytokine Res. 2002. PMID: 11911800

7

ELISA methods for the analysis of antibody responses induced in multiple sclerosis patients treated with recombinant interferon-beta.

Brickelmaier M, Hochman PS, Baciu R, Chao B, Cuervo JH, Whitty A. Brickelmaier M, et al. Among authors: whitty a. J Immunol Methods. 1999 Jul 30;227(1-2):121-35. doi: 10.1016/s0022-1759(99)00073-3. J Immunol Methods. 1999. PMID: 10485260

8

The resurgence of covalent drugs.

Singh J, Petter RC, Baillie TA, Whitty A. Singh J, et al. Among authors: whitty a. Nat Rev Drug Discov. 2011 Apr;10(4):307-17. doi: 10.1038/nrd3410. Nat Rev Drug Discov. 2011. PMID: 21455239 Review.

9

The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor.

Cate RL, di Clemente N, Racine C, Groome NP, Pepinsky RB, Whitty A. Cate RL, et al. Among authors: whitty a. J Biol Chem. 2022 Jan;298(1):101429. doi: 10.1016/j.jbc.2021.101429. Epub 2021 Nov 19. J Biol Chem. 2022. PMID: 34801555 Free PMC article.

10

Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.

Pepinsky RB, Mumford RA, Chen LL, Leone D, Amo SE, Riper GV, Whitty A, Dolinski B, Lobb RR, Dean DC, Chang LL, Raab CE, Si Q, Hagmann WK, Lingham RB. Pepinsky RB, et al. Among authors: whitty a. Biochemistry. 2002 Jun 4;41(22):7125-41. doi: 10.1021/bi020024d. Biochemistry. 2002. PMID: 12033947

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