Mathiesen JM - Search Results

1

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.

Mathiesen JM, Christopoulos A, Ulven T, Royer JF, Campillo M, Heinemann A, Pardo L, Kostenis E. Mathiesen JM, et al. Mol Pharmacol. 2006 Apr;69(4):1441-53. doi: 10.1124/mol.105.017681. Epub 2006 Jan 17. Mol Pharmacol. 2006. PMID: 16418339

2

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2.

Grimstrup M, Rist Ø, Receveur JM, Frimurer TM, Ulven T, Mathiesen JM, Kostenis E, Högberg T. Grimstrup M, et al. Among authors: mathiesen jm. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1181-5. doi: 10.1016/j.bmcl.2009.12.015. Epub 2009 Dec 6. Bioorg Med Chem Lett. 2010. PMID: 20022749

3

Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2.

Mathiesen JM, Ulven T, Martini L, Gerlach LO, Heinemann A, Kostenis E. Mathiesen JM, et al. Mol Pharmacol. 2005 Aug;68(2):393-402. doi: 10.1124/mol.104.010520. Epub 2005 May 3. Mol Pharmacol. 2005. PMID: 15870392

4

Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits.

Ulven T, Receveur JM, Grimstrup M, Rist Ø, Frimurer TM, Gerlach LO, Mathiesen JM, Kostenis E, Uller L, Högberg T. Ulven T, et al. Among authors: mathiesen jm. J Med Chem. 2006 Nov 16;49(23):6638-41. doi: 10.1021/jm060657g. J Med Chem. 2006. PMID: 17154491

5

Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.

Uller L, Mathiesen JM, Alenmyr L, Korsgren M, Ulven T, Högberg T, Andersson G, Persson CG, Kostenis E. Uller L, et al. Among authors: mathiesen jm. Respir Res. 2007 Feb 28;8(1):16. doi: 10.1186/1465-9921-8-16. Respir Res. 2007. PMID: 17328802 Free PMC article.

6

The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.

Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. Schröder R, et al. Among authors: mathiesen jm. J Biol Chem. 2009 Jan 9;284(2):1324-36. doi: 10.1074/jbc.M806867200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19010788 Free article.

7

Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists.

Grimstrup M, Receveur JM, Rist Ø, Frimurer TM, Nielsen PA, Mathiesen JM, Högberg T. Grimstrup M, et al. Among authors: mathiesen jm. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1638-41. doi: 10.1016/j.bmcl.2010.01.092. Epub 2010 Jan 22. Bioorg Med Chem Lett. 2010. PMID: 20137942

8

Delineation of molecular determinants for FR900359 inhibition of G_q/11 unlocks inhibition of Gα_s.

Boesgaard MW, Harpsøe K, Malmberg M, Underwood CR, Inoue A, Mathiesen JM, König GM, Kostenis E, Gloriam DE, Bräuner-Osborne H. Boesgaard MW, et al. Among authors: mathiesen jm. J Biol Chem. 2020 Oct 2;295(40):13850-13861. doi: 10.1074/jbc.RA120.013002. Epub 2020 Aug 4. J Biol Chem. 2020. PMID: 32753482 Free PMC article.

9

Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.

Mølck C, Harpsøe K, Gloriam DE, Clausen RP, Madsen U, Pedersen LØ, Jimenez HN, Nielsen SM, Mathiesen JM, Bräuner-Osborne H. Mølck C, et al. Among authors: mathiesen jm. Mol Pharmacol. 2012 Nov;82(5):929-37. doi: 10.1124/mol.112.078808. Epub 2012 Aug 16. Mol Pharmacol. 2012. PMID: 22899869

10

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.

Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Manglik A, et al. Among authors: mathiesen jm. Nature. 2012 Mar 21;485(7398):321-6. doi: 10.1038/nature10954. Nature. 2012. PMID: 22437502 Free PMC article.

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