Seeliger M - Search Results

1

Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.

Young MA, Shah NP, Chao LH, Seeliger M, Milanov ZV, Biggs WH 3rd, Treiber DK, Patel HK, Zarrinkar PP, Lockhart DJ, Sawyers CL, Kuriyan J. Young MA, et al. Among authors: seeliger m. Cancer Res. 2006 Jan 15;66(2):1007-14. doi: 10.1158/0008-5472.CAN-05-2788. Cancer Res. 2006. PMID: 16424036

2

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases.

Seeliger MA, Young M, Henderson MN, Pellicena P, King DS, Falick AM, Kuriyan J. Seeliger MA, et al. Protein Sci. 2005 Dec;14(12):3135-9. doi: 10.1110/ps.051750905. Epub 2005 Oct 31. Protein Sci. 2005. PMID: 16260764 Free PMC article.

3

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.

Nagar B, Hantschel O, Seeliger M, Davies JM, Weis WI, Superti-Furga G, Kuriyan J. Nagar B, et al. Among authors: seeliger m. Mol Cell. 2006 Mar 17;21(6):787-98. doi: 10.1016/j.molcel.2006.01.035. Mol Cell. 2006. PMID: 16543148 Free article.

4

c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty.

Seeliger MA, Nagar B, Frank F, Cao X, Henderson MN, Kuriyan J. Seeliger MA, et al. Structure. 2007 Mar;15(3):299-311. doi: 10.1016/j.str.2007.01.015. Structure. 2007. PMID: 17355866 Free article.

5

Structural basis for the recognition of c-Src by its inactivator Csk.

Levinson NM, Seeliger MA, Cole PA, Kuriyan J. Levinson NM, et al. Among authors: seeliger ma. Cell. 2008 Jul 11;134(1):124-34. doi: 10.1016/j.cell.2008.05.051. Cell. 2008. PMID: 18614016 Free PMC article.

6

Activation of tyrosine kinases by mutation of the gatekeeper threonine.

Azam M, Seeliger MA, Gray NS, Kuriyan J, Daley GQ. Azam M, et al. Among authors: seeliger ma. Nat Struct Mol Biol. 2008 Oct;15(10):1109-18. doi: 10.1038/nsmb.1486. Epub 2008 Sep 14. Nat Struct Mol Biol. 2008. PMID: 18794843 Free PMC article.

7

Tuning a three-component reaction for trapping kinase substrate complexes.

Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH 3rd, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM. Statsuk AV, et al. Among authors: seeliger ma. J Am Chem Soc. 2008 Dec 24;130(51):17568-74. doi: 10.1021/ja807066f. J Am Chem Soc. 2008. PMID: 19053485 Free PMC article.

8

A conserved protonation-dependent switch controls drug binding in the Abl kinase.

Shan Y, Seeliger MA, Eastwood MP, Frank F, Xu H, Jensen MØ, Dror RO, Kuriyan J, Shaw DE. Shan Y, et al. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):139-44. doi: 10.1073/pnas.0811223106. Epub 2008 Dec 24. Proc Natl Acad Sci U S A. 2009. PMID: 19109437 Free PMC article.

9

Comparative analysis of mutant tyrosine kinase chemical rescue.

Muratore KE, Seeliger MA, Wang Z, Fomina D, Neiswinger J, Havranek JJ, Baker D, Kuriyan J, Cole PA. Muratore KE, et al. Biochemistry. 2009 Apr 21;48(15):3378-86. doi: 10.1021/bi900057g. Biochemistry. 2009. PMID: 19260709 Free PMC article.

10

Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations.

Seeliger MA, Ranjitkar P, Kasap C, Shan Y, Shaw DE, Shah NP, Kuriyan J, Maly DJ. Seeliger MA, et al. Cancer Res. 2009 Mar 15;69(6):2384-92. doi: 10.1158/0008-5472.CAN-08-3953. Epub 2009 Mar 10. Cancer Res. 2009. PMID: 19276351 Free PMC article.

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