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Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals.
Sparks LM, Redman LM, Conley KE, Harper ME, Hodges A, Eroshkin A, Costford SR, Gabriel ME, Yi F, Shook C, Cornnell HH, Ravussin E, Smith SR. Sparks LM, et al. Among authors: costford sr. J Clin Endocrinol Metab. 2016 Dec;101(12):4994-5003. doi: 10.1210/jc.2016-2742. Epub 2016 Oct 6. J Clin Endocrinol Metab. 2016. PMID: 27710240 Free PMC article. Clinical Trial.
Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes.
Crawford SA, Costford SR, Aguer C, Thomas SC, deKemp RA, DaSilva JN, Lafontaine D, Kendall M, Dent R, Beanlands RS, McPherson R, Harper ME. Crawford SA, et al. Among authors: costford sr. Diabetologia. 2010 Sep;53(9):1986-97. doi: 10.1007/s00125-010-1788-7. Epub 2010 May 15. Diabetologia. 2010. PMID: 20473479
Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver.
Costford SR, Castro-Alves J, Chan KL, Bailey LJ, Woo M, Belsham DD, Brumell JH, Klip A. Costford SR, et al. Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1341-53. doi: 10.1152/ajpendo.00089.2014. Epub 2014 Apr 22. Am J Physiol Endocrinol Metab. 2014. PMID: 24760992 Free article.
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