Watts JK - Search Results

1

Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU).

Watts JK, Sadalapure K, Choubdar N, Pinto BM, Damha MJ. Watts JK, et al. J Org Chem. 2006 Feb 3;71(3):921-5. doi: 10.1021/jo051844+. J Org Chem. 2006. PMID: 16438502

2

2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.

Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Pinto BM, Damha MJ. Watts JK, et al. Nucleic Acids Res. 2007;35(5):1441-51. doi: 10.1093/nar/gkl1153. Epub 2007 Feb 6. Nucleic Acids Res. 2007. PMID: 17284457 Free PMC article.

3

Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide.

Watts JK, Johnston BD, Jayakanthan K, Wahba AS, Pinto BM, Damha MJ. Watts JK, et al. J Am Chem Soc. 2008 Jul 9;130(27):8578-9. doi: 10.1021/ja802205u. Epub 2008 Jun 11. J Am Chem Soc. 2008. PMID: 18543920

4

Chemically modified siRNA: tools and applications.

Watts JK, Deleavey GF, Damha MJ. Watts JK, et al. Drug Discov Today. 2008 Oct;13(19-20):842-55. doi: 10.1016/j.drudis.2008.05.007. Epub 2008 Jul 7. Drug Discov Today. 2008. PMID: 18614389 Review.

5

Studies on the hydrolytic stability of 2'-fluoroarabinonucleic acid (2'F-ANA).

Watts JK, Katolik A, Viladoms J, Damha MJ. Watts JK, et al. Org Biomol Chem. 2009 May 7;7(9):1904-10. doi: 10.1039/b900443b. Epub 2009 Mar 19. Org Biomol Chem. 2009. PMID: 19590787

6

Chemical modification of siRNA.

Deleavey GF, Watts JK, Damha MJ. Deleavey GF, et al. Among authors: watts jk. Curr Protoc Nucleic Acid Chem. 2009 Dec;Chapter 16:Unit 16.3. doi: 10.1002/0471142700.nc1603s39. Curr Protoc Nucleic Acid Chem. 2009. PMID: 20013783 Review.

7

Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility.

Watts JK, Martín-Pintado N, Gómez-Pinto I, Schwartzentruber J, Portella G, Orozco M, González C, Damha MJ. Watts JK, et al. Nucleic Acids Res. 2010 Apr;38(7):2498-511. doi: 10.1093/nar/gkp1225. Epub 2010 Jan 13. Nucleic Acids Res. 2010. PMID: 20071751 Free PMC article.

8

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing.

Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ. Deleavey GF, et al. Among authors: watts jk. Nucleic Acids Res. 2010 Jul;38(13):4547-57. doi: 10.1093/nar/gkq181. Epub 2010 Apr 22. Nucleic Acids Res. 2010. PMID: 20413581 Free PMC article.

9

Energetically important C-H···F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity.

Anzahaee MY, Watts JK, Alla NR, Nicholson AW, Damha MJ. Anzahaee MY, et al. Among authors: watts jk. J Am Chem Soc. 2011 Feb 2;133(4):728-31. doi: 10.1021/ja109817p. Epub 2010 Dec 20. J Am Chem Soc. 2011. PMID: 21171597

10

Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat.

Li L, Shen X, Liu Z, Norrbom M, Prakash TP, O'Reilly D, Sharma VK, Damha MJ, Watts JK, Rigo F, Corey DR. Li L, et al. Among authors: watts jk. Nucleic Acid Ther. 2018 Feb;28(1):23-33. doi: 10.1089/nat.2017.0703. Epub 2018 Jan 17. Nucleic Acid Ther. 2018. PMID: 29341839 Free PMC article.

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