Njoroge FG - Search Results

1

Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors.

Tong X, Guo Z, Wright-Minogue J, Xia E, Prongay A, Madison V, Qiu P, Venkatraman S, Velazquez F, Njoroge FG, Malcolm BA. Tong X, et al. Among authors: njoroge fg. Biochemistry. 2006 Feb 7;45(5):1353-61. doi: 10.1021/bi051565g. Biochemistry. 2006. PMID: 16445277

2

Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease.

Chen KX, Njoroge FG, Prongay A, Pichardo J, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4475-8. doi: 10.1016/j.bmcl.2005.07.033. Bioorg Med Chem Lett. 2005. PMID: 16112859

3

Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.

Chen KX, Njoroge FG, Arasappan A, Venkatraman S, Vibulbhan B, Yang W, Parekh TN, Pichardo J, Prongay A, Cheng KC, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. J Med Chem. 2006 Feb 9;49(3):995-1005. doi: 10.1021/jm050820s. J Med Chem. 2006. PMID: 16451065

4

P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.

Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V. Arasappan A, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. doi: 10.1016/j.bmcl.2006.05.022. Epub 2006 May 30. Bioorg Med Chem Lett. 2006. PMID: 16730985

5

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.

Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V. Prongay AJ, et al. Among authors: njoroge fg. J Med Chem. 2007 May 17;50(10):2310-8. doi: 10.1021/jm060173k. Epub 2007 Apr 20. J Med Chem. 2007. PMID: 17444623

6

Macrocyclic inhibitors of HCV NS3-4A protease: design and structure activity relationship.

Venkatraman S, Njoroge FG. Venkatraman S, et al. Among authors: njoroge fg. Curr Top Med Chem. 2007;7(13):1290-301. doi: 10.2174/156802607781212202. Curr Top Med Chem. 2007. PMID: 17627558 Review.

7

Characterization of resistance mutations against HCV ketoamide protease inhibitors.

Tong X, Bogen S, Chase R, Girijavallabhan V, Guo Z, Njoroge FG, Prongay A, Saksena A, Skelton A, Xia E, Ralston R. Tong X, et al. Among authors: njoroge fg. Antiviral Res. 2008 Mar;77(3):177-85. doi: 10.1016/j.antiviral.2007.11.010. Epub 2007 Dec 28. Antiviral Res. 2008. PMID: 18201776

8

Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.

Velázquez F, Venkatraman S, Blackman M, Pinto P, Bogen S, Sannigrahi M, Chen K, Pichardo J, Hart A, Tong X, Girijavallabhan V, Njoroge FG. Velázquez F, et al. Among authors: njoroge fg. J Med Chem. 2009 Feb 12;52(3):700-8. doi: 10.1021/jm801201u. J Med Chem. 2009. PMID: 19154150

9

Macrocyclic inhibitors of HCV NS3 protease.

Venkatraman S, Njoroge FG. Venkatraman S, et al. Among authors: njoroge fg. Expert Opin Ther Pat. 2009 Sep;19(9):1277-303. doi: 10.1517/13543770903044994. Expert Opin Ther Pat. 2009. PMID: 19563268 Review.

10

Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups.

Venkatraman S, Velazquez F, Wu W, Blackman M, Madison V, Njoroge FG. Venkatraman S, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2151-5. doi: 10.1016/j.bmcl.2010.02.051. Epub 2010 Feb 14. Bioorg Med Chem Lett. 2010. PMID: 20226659

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