Kirkpatrick DL - Search Results

1

The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma.

Baker AF, Dragovich T, Tate WR, Ramanathan RK, Roe D, Hsu CH, Kirkpatrick DL, Powis G. Baker AF, et al. Among authors: kirkpatrick dl. J Lab Clin Med. 2006 Feb;147(2):83-90. doi: 10.1016/j.lab.2005.09.001. J Lab Clin Med. 2006. PMID: 16459166 Free PMC article. Clinical Trial.

2

The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

Welsh SJ, Williams RR, Birmingham A, Newman DJ, Kirkpatrick DL, Powis G. Welsh SJ, et al. Among authors: kirkpatrick dl. Mol Cancer Ther. 2003 Mar;2(3):235-43. Mol Cancer Ther. 2003. PMID: 12657718

3

Thioredoxin redox control of cell growth and death and the effects of inhibitors.

Powis G, Kirkpatrick DL, Angulo M, Baker A. Powis G, et al. Among authors: kirkpatrick dl. Chem Biol Interact. 1998 Apr 24;111-112:23-34. doi: 10.1016/s0009-2797(97)00148-8. Chem Biol Interact. 1998. PMID: 9679540 Review.

4

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts.

Ihle NT, Paine-Murrieta G, Berggren MI, Baker A, Tate WR, Wipf P, Abraham RT, Kirkpatrick DL, Powis G. Ihle NT, et al. Among authors: kirkpatrick dl. Mol Cancer Ther. 2005 Sep;4(9):1349-57. doi: 10.1158/1535-7163.MCT-05-0149. Mol Cancer Ther. 2005. PMID: 16170026 Free PMC article.

5

Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase.

Powis G, Wipf P, Lynch SM, Birmingham A, Kirkpatrick DL. Powis G, et al. Among authors: kirkpatrick dl. Mol Cancer Ther. 2006 Mar;5(3):630-6. doi: 10.1158/1535-7163.MCT-05-0487. Mol Cancer Ther. 2006. PMID: 16546977 Free PMC article.

6

A Phase I pharmacokinetic and pharmacodynamic study of PX-12, a novel inhibitor of thioredoxin-1, in patients with advanced solid tumors.

Ramanathan RK, Kirkpatrick DL, Belani CP, Friedland D, Green SB, Chow HH, Cordova CA, Stratton SP, Sharlow ER, Baker A, Dragovich T. Ramanathan RK, et al. Among authors: kirkpatrick dl. Clin Cancer Res. 2007 Apr 1;13(7):2109-14. doi: 10.1158/1078-0432.CCR-06-2250. Clin Cancer Res. 2007. PMID: 17404093 Clinical Trial.

7

Thioredoxin signaling as a target for cancer therapy.

Powis G, Kirkpatrick DL. Powis G, et al. Among authors: kirkpatrick dl. Curr Opin Pharmacol. 2007 Aug;7(4):392-7. doi: 10.1016/j.coph.2007.04.003. Epub 2007 Jul 3. Curr Opin Pharmacol. 2007. PMID: 17611157 Review.

8

Cell line-directed screening assay for inhibitors of thioredoxin reductase signaling as potential anti-cancer drugs.

Kunkel MW, Kirkpatrick DL, Johnson JI, Powis G. Kunkel MW, et al. Among authors: kirkpatrick dl. Anticancer Drug Des. 1997 Dec;12(8):659-70. Anticancer Drug Des. 1997. PMID: 9448705

9

A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers.

Baker AF, Adab KN, Raghunand N, Chow H, Stratton SP, Squire SW, Boice M, Pestano LA, Kirkpatrick DL, Dragovich T. Baker AF, et al. Among authors: kirkpatrick dl. Invest New Drugs. 2013 Jun;31(3):631-641. doi: 10.1007/s10637-012-9846-2. Epub 2012 Jun 19. Invest New Drugs. 2013. PMID: 22711542 Free PMC article. Clinical Trial.

10

Reversible inhibition of human thioredoxin reductase activity by cytotoxic alkyl 2-imidazolyl disulfide analogues.

Oblong JE, Chantler EL, Gallegos A, Kirkpatrick DL, Chen T, Marshall N, Powis G. Oblong JE, et al. Among authors: kirkpatrick dl. Cancer Chemother Pharmacol. 1994;34(5):434-8. Cancer Chemother Pharmacol. 1994. PMID: 8070012

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