Roberts AG - Search Results

1

NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity.

Roberts AG, Díaz MD, Lampe JN, Shireman LM, Grinstead JS, Dabrowski MJ, Pearson JT, Bowman MK, Atkins WM, Campbell AP. Roberts AG, et al. Biochemistry. 2006 Feb 14;45(6):1673-84. doi: 10.1021/bi0518895. Biochemistry. 2006. PMID: 16460014

2

Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production.

Muller FL, Roberts AG, Bowman MK, Kramer DM. Muller FL, et al. Among authors: roberts ag. Biochemistry. 2003 Jun 3;42(21):6493-9. doi: 10.1021/bi0342160. Biochemistry. 2003. PMID: 12767232

3

The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria.

Roberts AG, Campbell AP, Atkins WM. Roberts AG, et al. Biochemistry. 2005 Feb 1;44(4):1353-66. doi: 10.1021/bi0481390. Biochemistry. 2005. PMID: 15667229

4

Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry.

Wen B, Doneanu CE, Gartner CA, Roberts AG, Atkins WM, Nelson SD. Wen B, et al. Among authors: roberts ag. Biochemistry. 2005 Feb 15;44(6):1833-45. doi: 10.1021/bi048228c. Biochemistry. 2005. PMID: 15697209

5

Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.

Cameron MD, Wen B, Allen KE, Roberts AG, Schuman JT, Campbell AP, Kunze KL, Nelson SD. Cameron MD, et al. Among authors: roberts ag. Biochemistry. 2005 Nov 1;44(43):14143-51. doi: 10.1021/bi051689t. Biochemistry. 2005. PMID: 16245930

6

Probing the CYP3A4 active site by cysteine scanning mutagenesis and photoaffinity labeling.

Wen B, Doneanu CE, Lampe JN, Roberts AG, Atkins WM, Nelson SD. Wen B, et al. Among authors: roberts ag. Arch Biochem Biophys. 2005 Dec 15;444(2):100-11. doi: 10.1016/j.abb.2005.09.010. Epub 2005 Oct 21. Arch Biochem Biophys. 2005. PMID: 16289363

7

Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase.

Wen B, Lampe JN, Roberts AG, Atkins WM, David Rodrigues A, Nelson SD. Wen B, et al. Among authors: roberts ag. Arch Biochem Biophys. 2006 Oct 1;454(1):42-54. doi: 10.1016/j.abb.2006.08.003. Epub 2006 Aug 22. Arch Biochem Biophys. 2006. PMID: 16959210 Free PMC article.

8

Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4.

Roberts AG, Atkins WM. Roberts AG, et al. Arch Biochem Biophys. 2007 Jul 1;463(1):89-101. doi: 10.1016/j.abb.2007.03.006. Epub 2007 Apr 2. Arch Biochem Biophys. 2007. PMID: 17459328 Free PMC article.

9

Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.

Cameron MD, Wen B, Roberts AG, Atkins WM, Campbell AP, Nelson SD. Cameron MD, et al. Among authors: roberts ag. Chem Res Toxicol. 2007 Oct;20(10):1434-41. doi: 10.1021/tx7000702. Epub 2007 Sep 26. Chem Res Toxicol. 2007. PMID: 17894464

10

Intramolecular heme ligation of the cytochrome P450 2C9 R108H mutant demonstrates pronounced conformational flexibility of the B-C loop region: implications for substrate binding.

Roberts AG, Cheesman MJ, Primak A, Bowman MK, Atkins WM, Rettie AE. Roberts AG, et al. Biochemistry. 2010 Oct 12;49(40):8700-8. doi: 10.1021/bi100911q. Epub 2010 Sep 21. Biochemistry. 2010. PMID: 20815369 Free PMC article.

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