Abell C - Search Results

1

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Howard N, et al. Among authors: abell c. J Med Chem. 2006 Feb 23;49(4):1346-55. doi: 10.1021/jm050850v. J Med Chem. 2006. PMID: 16480269

2

High-throughput crystallography for lead discovery in drug design.

Blundell TL, Jhoti H, Abell C. Blundell TL, et al. Among authors: abell c. Nat Rev Drug Discov. 2002 Jan;1(1):45-54. doi: 10.1038/nrd706. Nat Rev Drug Discov. 2002. PMID: 12119609 Review.

3

Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase.

Toscano MD, Frederickson M, Evans DP, Coggins JR, Abell C, González-Bello C. Toscano MD, et al. Among authors: abell c. Org Biomol Chem. 2003 Jun 21;1(12):2075-83. doi: 10.1039/b301731a. Org Biomol Chem. 2003. PMID: 12945898

4

A novel phase-switching protecting group for multi-step parallel solution phase synthesis.

Li X, Abell C, Congreve MS, Warrington BH, Ladlow M. Li X, et al. Among authors: abell c. Org Biomol Chem. 2004 Apr 7;2(7):989-98. doi: 10.1039/b400110a. Epub 2004 Feb 25. Org Biomol Chem. 2004. PMID: 15034621

5

Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica.

Kerbarh O, Ciulli A, Howard NI, Abell C. Kerbarh O, et al. Among authors: abell c. J Bacteriol. 2005 Aug;187(15):5061-6. doi: 10.1128/JB.187.15.5061-5066.2005. J Bacteriol. 2005. PMID: 16030197 Free PMC article.

6

Rational design of new bifunctional inhibitors of type II dehydroquinase.

Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C. Toscano MD, et al. Among authors: abell c. Org Biomol Chem. 2005 Sep 7;3(17):3102-4. doi: 10.1039/b507156a. Epub 2005 Aug 1. Org Biomol Chem. 2005. PMID: 16106291

7

Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.

Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Ciulli A, et al. Among authors: abell c. J Med Chem. 2006 Aug 10;49(16):4992-5000. doi: 10.1021/jm060490r. J Med Chem. 2006. PMID: 16884311

8

Fragment-based approaches to enzyme inhibition.

Ciulli A, Abell C. Ciulli A, et al. Among authors: abell c. Curr Opin Biotechnol. 2007 Dec;18(6):489-96. doi: 10.1016/j.copbio.2007.09.003. Epub 2007 Oct 24. Curr Opin Biotechnol. 2007. PMID: 17959370 Free PMC article. Review.

9

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.

Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Hung AW, et al. Among authors: abell c. Angew Chem Int Ed Engl. 2009;48(45):8452-6. doi: 10.1002/anie.200903821. Angew Chem Int Ed Engl. 2009. PMID: 19780086 No abstract available.

10

Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes.

Sridharan S, Howard N, Kerbarh O, Błaszczyk M, Abell C, Blundell TL. Sridharan S, et al. Among authors: abell c. J Mol Biol. 2010 Mar 19;397(1):290-300. doi: 10.1016/j.jmb.2010.01.019. Epub 2010 Jan 15. J Mol Biol. 2010. PMID: 20079748

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