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Page 1
Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.
Tuccinardi T, Martinelli A, Nuti E, Carelli P, Balzano F, Uccello-Barretta G, Murphy G, Rossello A. Tuccinardi T, et al. Among authors: martinelli a. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76. doi: 10.1016/j.bmc.2006.01.056. Epub 2006 Feb 17. Bioorg Med Chem. 2006. PMID: 16483784
Adenosine receptor modelling. A1/A2a selectivity.
Tuccinardi T, Ortore G, Manera C, Saccomanni G, Martinelli A. Tuccinardi T, et al. Among authors: martinelli a. Eur J Med Chem. 2006 Mar;41(3):321-9. doi: 10.1016/j.ejmech.2005.09.011. Epub 2006 Jan 19. Eur J Med Chem. 2006. PMID: 16427161
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Nuti E, Casalini F, Avramova SI, Santamaria S, Cercignani G, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Tuccinardi T, Martinelli A, Lim NH, Visse R, Nagase H, Rossello A. Nuti E, et al. Among authors: martinelli a. J Med Chem. 2009 Aug 13;52(15):4757-73. doi: 10.1021/jm900261f. J Med Chem. 2009. PMID: 19606871
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
Nuti E, Panelli L, Casalini F, Avramova SI, Orlandini E, Santamaria S, Nencetti S, Tuccinardi T, Martinelli A, Cercignani G, D'Amelio N, Maiocchi A, Uggeri F, Rossello A. Nuti E, et al. Among authors: martinelli a. J Med Chem. 2009 Oct 22;52(20):6347-61. doi: 10.1021/jm900335a. J Med Chem. 2009. PMID: 19775099
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
Nuti E, Cantelmo AR, Gallo C, Bruno A, Bassani B, Camodeca C, Tuccinardi T, Vera L, Orlandini E, Nencetti S, Stura EA, Martinelli A, Dive V, Albini A, Rossello A. Nuti E, et al. Among authors: martinelli a. J Med Chem. 2015 Sep 24;58(18):7224-40. doi: 10.1021/acs.jmedchem.5b00367. Epub 2015 Aug 28. J Med Chem. 2015. PMID: 26263024 Free article.
Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.
Balsamo A, Coletta I, Guglielmotti A, Landolfi C, Mancini F, Martinelli A, Milanese C, Minutolo F, Nencetti S, Orlandini E, Pinza M, Rapposelli S, Rossello A. Balsamo A, et al. Among authors: martinelli a. Eur J Med Chem. 2003 Feb;38(2):157-68. doi: 10.1016/s0223-5234(02)01448-4. Eur J Med Chem. 2003. PMID: 12620660
810 results