Riordan JR - Search Results

1

The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.

Cui L, Aleksandrov L, Hou YX, Gentzsch M, Chen JH, Riordan JR, Aleksandrov AA. Cui L, et al. Among authors: riordan jr. J Physiol. 2006 Apr 15;572(Pt 2):347-58. doi: 10.1113/jphysiol.2005.099457. Epub 2006 Feb 16. J Physiol. 2006. PMID: 16484308 Free PMC article.

2

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive.

Hegedus T, Aleksandrov A, Cui L, Gentzsch M, Chang XB, Riordan JR. Hegedus T, et al. Among authors: riordan jr. Biochim Biophys Acta. 2006 May;1758(5):565-72. doi: 10.1016/j.bbamem.2006.03.006. Epub 2006 Mar 31. Biochim Biophys Acta. 2006. PMID: 16624253 Free article.

3

CFTR (ABCC7) is a hydrolyzable-ligand-gated channel.

Aleksandrov AA, Aleksandrov LA, Riordan JR. Aleksandrov AA, et al. Among authors: riordan jr. Pflugers Arch. 2007 Feb;453(5):693-702. doi: 10.1007/s00424-006-0140-z. Epub 2006 Sep 26. Pflugers Arch. 2007. PMID: 17021796 Review.

4

Domain interdependence in the biosynthetic assembly of CFTR.

Cui L, Aleksandrov L, Chang XB, Hou YX, He L, Hegedus T, Gentzsch M, Aleksandrov A, Balch WE, Riordan JR. Cui L, et al. Among authors: riordan jr. J Mol Biol. 2007 Jan 26;365(4):981-94. doi: 10.1016/j.jmb.2006.10.086. Epub 2006 Nov 10. J Mol Biol. 2007. PMID: 17113596

5

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function.

Serohijos AW, Hegedus T, Aleksandrov AA, He L, Cui L, Dokholyan NV, Riordan JR. Serohijos AW, et al. Among authors: riordan jr. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3256-61. doi: 10.1073/pnas.0800254105. Epub 2008 Feb 27. Proc Natl Acad Sci U S A. 2008. PMID: 18305154 Free PMC article.

6

Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2).

Aleksandrov L, Aleksandrov A, Riordan JR. Aleksandrov L, et al. Among authors: riordan jr. Biochem J. 2008 Nov 15;416(1):129-36. doi: 10.1042/BJ20081068. Biochem J. 2008. PMID: 18605986

7

Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating.

He L, Aleksandrov AA, Serohijos AW, Hegedus T, Aleksandrov LA, Cui L, Dokholyan NV, Riordan JR. He L, et al. Among authors: riordan jr. J Biol Chem. 2008 Sep 26;283(39):26383-90. doi: 10.1074/jbc.M803894200. Epub 2008 Jul 25. J Biol Chem. 2008. PMID: 18658148 Free PMC article.

8

Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator.

Aleksandrov AA, Cui L, Riordan JR. Aleksandrov AA, et al. Among authors: riordan jr. J Physiol. 2009 Jun 15;587(Pt 12):2875-86. doi: 10.1113/jphysiol.2009.170258. Epub 2009 Apr 29. J Physiol. 2009. PMID: 19403599 Free PMC article.

9

Restoration of domain folding and interdomain assembly by second-site suppressors of the DeltaF508 mutation in CFTR.

He L, Aleksandrov LA, Cui L, Jensen TJ, Nesbitt KL, Riordan JR. He L, et al. Among authors: riordan jr. FASEB J. 2010 Aug;24(8):3103-12. doi: 10.1096/fj.09-141788. Epub 2010 Mar 16. FASEB J. 2010. PMID: 20233947 Free PMC article.

10

Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR.

Aleksandrov AA, Kota P, Aleksandrov LA, He L, Jensen T, Cui L, Gentzsch M, Dokholyan NV, Riordan JR. Aleksandrov AA, et al. Among authors: riordan jr. J Mol Biol. 2010 Aug 13;401(2):194-210. doi: 10.1016/j.jmb.2010.06.019. Epub 2010 Jun 16. J Mol Biol. 2010. PMID: 20561529 Free PMC article.

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