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N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake.
Boot JR, Boulet SL, Clark BP, Cases-Thomas MJ, Delhaye L, Diker K, Fairhurst J, Findlay J, Gallagher PT, Gilmore J, Harris JR, Masters JJ, Mitchell SN, Naik M, Simmonds RG, Smith SM, Richards SJ, Timms GH, Whatton MA, Wolfe CN, Wood VA. Boot JR, et al. Among authors: gallagher pt. Bioorg Med Chem Lett. 2006 May 15;16(10):2714-8. doi: 10.1016/j.bmcl.2006.02.008. Epub 2006 Feb 23. Bioorg Med Chem Lett. 2006. PMID: 16497500
Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter.
Cases-Thomas MJ, Masters JJ, Walter MW, Campbell G, Haughton L, Gallagher PT, Dobson DR, Mancuso V, Bonnier B, Giard T, Defrance T, Vanmarsenille M, Ledgard A, White C, Ouwerkerk-Mahadevan S, Brunelle FJ, Dezutter NA, Herbots CA, Lienard JY, Findlay J, Hayhurst L, Boot J, Thompson LK, Hemrick-Luecke S. Cases-Thomas MJ, et al. Among authors: gallagher pt. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2022-5. doi: 10.1016/j.bmcl.2005.12.061. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413778
Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.
Bymaster FP, Beedle EE, Findlay J, Gallagher PT, Krushinski JH, Mitchell S, Robertson DW, Thompson DC, Wallace L, Wong DT. Bymaster FP, et al. Among authors: gallagher pt. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4477-80. doi: 10.1016/j.bmcl.2003.08.079. Bioorg Med Chem Lett. 2003. PMID: 14643350
17 results