Ohta T - Search Results

1

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.

Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M. Padmanabhan B, et al. Among authors: ohta t. Mol Cell. 2006 Mar 3;21(5):689-700. doi: 10.1016/j.molcel.2006.01.013. Mol Cell. 2006. PMID: 16507366 Free article.

2

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Yokota J, Sakiyama T, Shibata T, Yamamoto M, Hirohashi S. Ohta T, et al. Cancer Res. 2008 Mar 1;68(5):1303-9. doi: 10.1158/0008-5472.CAN-07-5003. Cancer Res. 2008. PMID: 18316592

3

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.

Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S. Shibata T, et al. Among authors: ohta t. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13568-73. doi: 10.1073/pnas.0806268105. Epub 2008 Aug 29. Proc Natl Acad Sci U S A. 2008. PMID: 18757741 Free PMC article.

4

Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes.

Kobayashi A, Ohta T, Yamamoto M. Kobayashi A, et al. Among authors: ohta t. Methods Enzymol. 2004;378:273-86. doi: 10.1016/S0076-6879(04)78021-0. Methods Enzymol. 2004. PMID: 15038975 Review. No abstract available.

5

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer.

Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S. Shibata T, et al. Among authors: ohta t. Gastroenterology. 2008 Oct;135(4):1358-1368, 1368.e1-4. doi: 10.1053/j.gastro.2008.06.082. Epub 2008 Jul 3. Gastroenterology. 2008. PMID: 18692501

6

BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress.

Zhang J, Ohta T, Maruyama A, Hosoya T, Nishikawa K, Maher JM, Shibahara S, Itoh K, Yamamoto M. Zhang J, et al. Among authors: ohta t. Mol Cell Biol. 2006 Nov;26(21):7942-52. doi: 10.1128/MCB.00700-06. Epub 2006 Aug 21. Mol Cell Biol. 2006. PMID: 16923960 Free PMC article.

7

Expression and purification of recombinant human histones.

Tanaka Y, Tawaramoto-Sasanuma M, Kawaguchi S, Ohta T, Yoda K, Kurumizaka H, Yokoyama S. Tanaka Y, et al. Among authors: ohta t. Methods. 2004 May;33(1):3-11. doi: 10.1016/j.ymeth.2003.10.024. Methods. 2004. PMID: 15039081

8

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.

Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, Yamamoto M. Zhang J, et al. Among authors: ohta t. Biochem J. 2007 Jun 15;404(3):459-66. doi: 10.1042/BJ20061611. Biochem J. 2007. PMID: 17313370 Free PMC article.

9

PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.

Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, Ohta T, Ichikawa H, Aburatani H, Tashiro F, Taya Y. Kawase T, et al. Among authors: ohta t. Cell. 2009 Feb 6;136(3):535-50. doi: 10.1016/j.cell.2008.12.002. Cell. 2009. PMID: 19203586 Free article.

10

A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability.

Yamamoto Y, Miyamoto M, Tatsuda D, Kubo M, Nakagama H, Nakamura Y, Satoh H, Matsuda K, Watanabe T, Ohta T. Yamamoto Y, et al. Among authors: ohta t. Cancer Res. 2014 Jul 15;74(14):3707-15. doi: 10.1158/0008-5472.CAN-13-3037. Epub 2014 May 15. Cancer Res. 2014. PMID: 24830725

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