Schiffer CA - Search Results

1

Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.

Prabu-Jeyabalan M, Nalivaika EA, Romano K, Schiffer CA. Prabu-Jeyabalan M, et al. Among authors: schiffer ca. J Virol. 2006 Apr;80(7):3607-16. doi: 10.1128/JVI.80.7.3607-3616.2006. J Virol. 2006. PMID: 16537628 Free PMC article.

2

How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease.

Prabu-Jeyabalan M, Nalivaika E, Schiffer CA. Prabu-Jeyabalan M, et al. Among authors: schiffer ca. J Mol Biol. 2000 Sep 1;301(5):1207-20. doi: 10.1006/jmbi.2000.4018. J Mol Biol. 2000. PMID: 10966816

3

Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance.

Scott WR, Schiffer CA. Scott WR, et al. Among authors: schiffer ca. Structure. 2000 Dec 15;8(12):1259-65. doi: 10.1016/s0969-2126(00)00537-2. Structure. 2000. PMID: 11188690 Free article.

4

Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.

King NM, Melnick L, Prabu-Jeyabalan M, Nalivaika EA, Yang SS, Gao Y, Nie X, Zepp C, Heefner DL, Schiffer CA. King NM, et al. Among authors: schiffer ca. Protein Sci. 2002 Feb;11(2):418-29. doi: 10.1110/ps.25502. Protein Sci. 2002. PMID: 11790852 Free PMC article.

5

Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes.

Prabu-Jeyabalan M, Nalivaika E, Schiffer CA. Prabu-Jeyabalan M, et al. Among authors: schiffer ca. Structure. 2002 Mar;10(3):369-81. doi: 10.1016/s0969-2126(02)00720-7. Structure. 2002. PMID: 12005435 Free article.

6

Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease.

Pettit SC, Henderson GJ, Schiffer CA, Swanstrom R. Pettit SC, et al. Among authors: schiffer ca. J Virol. 2002 Oct;76(20):10226-33. doi: 10.1128/jvi.76.20.10226-10233.2002. J Virol. 2002. PMID: 12239298 Free PMC article.

7

Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy.

Prabu-Jeyabalan M, Nalivaika EA, King NM, Schiffer CA. Prabu-Jeyabalan M, et al. Among authors: schiffer ca. J Virol. 2003 Jan;77(2):1306-15. doi: 10.1128/jvi.77.2.1306-1315.2003. J Virol. 2003. PMID: 12502847 Free PMC article.

8

Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments.

Wu TD, Schiffer CA, Gonzales MJ, Taylor J, Kantor R, Chou S, Israelski D, Zolopa AR, Fessel WJ, Shafer RW. Wu TD, et al. Among authors: schiffer ca. J Virol. 2003 Apr;77(8):4836-47. doi: 10.1128/jvi.77.8.4836-4847.2003. J Virol. 2003. PMID: 12663790 Free PMC article.

9

Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor.

King NM, Prabu-Jeyabalan M, Nalivaika EA, Wigerinck P, de Béthune MP, Schiffer CA. King NM, et al. Among authors: schiffer ca. J Virol. 2004 Nov;78(21):12012-21. doi: 10.1128/JVI.78.21.12012-12021.2004. J Virol. 2004. PMID: 15479840 Free PMC article.

10

Combating susceptibility to drug resistance: lessons from HIV-1 protease.

King NM, Prabu-Jeyabalan M, Nalivaika EA, Schiffer CA. King NM, et al. Among authors: schiffer ca. Chem Biol. 2004 Oct;11(10):1333-8. doi: 10.1016/j.chembiol.2004.08.010. Chem Biol. 2004. PMID: 15489160

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