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Estrogens and antiestrogens activate hPXR.
Mnif W, Pascussi JM, Pillon A, Escande A, Bartegi A, Nicolas JC, Cavaillès V, Duchesne MJ, Balaguer P. Mnif W, et al. Among authors: pascussi jm. Toxicol Lett. 2007 Apr 5;170(1):19-29. doi: 10.1016/j.toxlet.2006.11.016. Epub 2007 Feb 16. Toxicol Lett. 2007. PMID: 17379461
Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.
Duret C, Daujat-Chavanieu M, Pascussi JM, Pichard-Garcia L, Balaguer P, Fabre JM, Vilarem MJ, Maurel P, Gerbal-Chaloin S. Duret C, et al. Among authors: pascussi jm. Mol Pharmacol. 2006 Jul;70(1):329-39. doi: 10.1124/mol.105.022046. Epub 2006 Apr 11. Mol Pharmacol. 2006. PMID: 16608920
Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.
Briolotti P, Chaloin L, Balaguer P, Da Silva F, Tománková V, Pascussi JM, Duret C, Fabre JM, Ramos J, Klieber S, Maurel P, Daujat-Chavanieu M, Gerbal-Chaloin S. Briolotti P, et al. Among authors: pascussi jm. Toxicol Sci. 2015 Nov;148(1):261-75. doi: 10.1093/toxsci/kfv177. Epub 2015 Aug 10. Toxicol Sci. 2015. PMID: 26259606
Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.
Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W. Delfosse V, et al. Among authors: pascussi jm. Nat Commun. 2015 Sep 3;6:8089. doi: 10.1038/ncomms9089. Nat Commun. 2015. PMID: 26333997 Free PMC article.
N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.
Benod C, Subra G, Nahoum V, Mallavialle A, Guichou JF, Milhau J, Roblés S, Bourguet W, Pascussi JM, Balaguer P, Chavanieu A. Benod C, et al. Among authors: pascussi jm. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49. doi: 10.1016/j.bmc.2008.02.020. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18304819
A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.
Moreau A, Téruel C, Beylot M, Albalea V, Tamasi V, Umbdenstock T, Parmentier Y, Sa-Cunha A, Suc B, Fabre JM, Navarro F, Ramos J, Meyer U, Maurel P, Vilarem MJ, Pascussi JM. Moreau A, et al. Among authors: pascussi jm. Hepatology. 2009 Jun;49(6):2068-79. doi: 10.1002/hep.22907. Hepatology. 2009. PMID: 19437491
87 results