Holdsworth DL - Search Results

1

A one-step approach to the analysis of the QT interval in conscious telemetrized dogs.

Chiang AY, Holdsworth DL, Leishman DJ. Chiang AY, et al. Among authors: holdsworth dl. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):183-8. doi: 10.1016/j.vascn.2006.02.004. Epub 2006 Mar 6. J Pharmacol Toxicol Methods. 2006. PMID: 16567113

2

Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation.

Holdsworth D, Best DD, Haist K, O'Donohue K, Phillips A, Abernathy MM, Roche B, Leishman DJ. Holdsworth D, et al. J Pharmacol Toxicol Methods. 2023 Mar-Apr;120:107253. doi: 10.1016/j.vascn.2023.107253. Epub 2023 Feb 16. J Pharmacol Toxicol Methods. 2023. PMID: 36806737

3

Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates.

Leishman DJ, Holdsworth DL, Best DD, Roche BM. Leishman DJ, et al. Among authors: holdsworth dl. J Pharmacol Toxicol Methods. 2023 Sep-Oct;123:107299. doi: 10.1016/j.vascn.2023.107299. Epub 2023 Jul 24. J Pharmacol Toxicol Methods. 2023. PMID: 37495163

4

The "One-Step" approach for QT analysis increases the sensitivity of nonclinical QTc analysis.

Leishman DJ, Holdsworth DL, Lauver DA, Bailie MB, Roche BM. Leishman DJ, et al. Among authors: holdsworth dl. Clin Transl Sci. 2023 Nov;16(11):2253-2264. doi: 10.1111/cts.13625. Epub 2023 Sep 19. Clin Transl Sci. 2023. PMID: 37726963 Free PMC article.

5

Demonstrating the statistical and pharmacological sensitivity of nonclinical QTc analysis using a dofetilide dose-response in nonhuman primates.

Leishman DJ, Holdsworth DL, Best DD, Abernathy MM, Roche BM. Leishman DJ, et al. Among authors: holdsworth dl. J Pharmacol Toxicol Methods. 2024 Dec 15:107572. doi: 10.1016/j.vascn.2024.107572. Online ahead of print. J Pharmacol Toxicol Methods. 2024. PMID: 39689735

6

Effects of telemetric epicardial leads and ventricular catheters on arrhythmia incidence in cynomolgus monkeys.

Holdsworth DL, O'Donohue KP, Yoder JD, Gesaman JE, Dalton JA, Gauvin DV, Tilley LP, Smith FW Jr, Baird TJ. Holdsworth DL, et al. J Pharmacol Toxicol Methods. 2014 Mar-Apr;69(2):167-76. doi: 10.1016/j.vascn.2013.11.001. Epub 2013 Nov 18. J Pharmacol Toxicol Methods. 2014. PMID: 24262389

7

A predictive index of biomarkers for ictogenesis from tier I safety pharmacology testing that may warrant tier II EEG studies.

Gauvin DV, Zimmermann ZJ, Yoder J, Harter M, Holdsworth D, Kilgus Q, May J, Dalton J, Baird TJ. Gauvin DV, et al. J Pharmacol Toxicol Methods. 2018 Nov-Dec;94(Pt 1):50-63. doi: 10.1016/j.vascn.2018.05.002. Epub 2018 May 8. J Pharmacol Toxicol Methods. 2018. PMID: 29751085 Review.

8

Relative equivalence of CNS safety (FOB) assessment outcomes in male and female Wistar-Han and Sprague-Dawley rats.

Gauvin DV, Dalton JA, Harter ML, Holdsworth D, May J, Tapp R, Zimmermann ZJ, Kilgus Q, Baird TJ. Gauvin DV, et al. J Pharmacol Toxicol Methods. 2019 Jan-Feb;95:2-11. doi: 10.1016/j.vascn.2018.11.002. Epub 2018 Nov 23. J Pharmacol Toxicol Methods. 2019. PMID: 30476622

9

The standardized functional observational battery: Its intrinsic value remains in the instrument of measure: The rat.

Gauvin DV, Yoder JD, Holdsworth DL, Harter ML, May JR, Cotey N, Dalton JA, Baird TJ. Gauvin DV, et al. Among authors: holdsworth dl. J Pharmacol Toxicol Methods. 2016 Nov-Dec;82:90-108. doi: 10.1016/j.vascn.2016.08.001. Epub 2016 Aug 14. J Pharmacol Toxicol Methods. 2016. PMID: 27534836 Review.

10

Very regular high-frequency pulsation modes in young intermediate-mass stars.

Bedding TR, Murphy SJ, Hey DR, Huber D, Li T, Smalley B, Stello D, White TR, Ball WH, Chaplin WJ, Colman IL, Fuller J, Gaidos E, Harbeck DR, Hermes JJ, Holdsworth DL, Li G, Li Y, Mann AW, Reese DR, Sekaran S, Yu J, Antoci V, Bergmann C, Brown TM, Howard AW, Ireland MJ, Isaacson H, Jenkins JM, Kjeldsen H, McCully C, Rabus M, Rains AD, Ricker GR, Tinney CG, Vanderspek RK. Bedding TR, et al. Among authors: holdsworth dl. Nature. 2020 May;581(7807):147-151. doi: 10.1038/s41586-020-2226-8. Epub 2020 May 13. Nature. 2020. PMID: 32405022

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