Halpert JR - Search Results

1

Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies.

Mast N, Murtazina D, Liu H, Graham SE, Bjorkhem I, Halpert JR, Peterson J, Pikuleva IA. Mast N, et al. Among authors: halpert jr. Biochemistry. 2006 Apr 11;45(14):4396-404. doi: 10.1021/bi052654w. Biochemistry. 2006. PMID: 16584175

2

Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.

Spatzenegger M, Liu H, Wang Q, Debarber A, Koop DR, Halpert JR. Spatzenegger M, et al. Among authors: halpert jr. J Pharmacol Exp Ther. 2003 Jan;304(1):477-87. doi: 10.1124/jpet.102.043323. J Pharmacol Exp Ther. 2003. PMID: 12490624

3

A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.

Kumar S, Scott EE, Liu H, Halpert JR. Kumar S, et al. Among authors: halpert jr. J Biol Chem. 2003 May 9;278(19):17178-84. doi: 10.1074/jbc.M212515200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12609983 Free article.

4

Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix.

Scott EE, Liu H, Qun He Y, Li W, Halpert JR. Scott EE, et al. Among authors: halpert jr. Arch Biochem Biophys. 2004 Mar 15;423(2):266-76. doi: 10.1016/j.abb.2003.12.035. Arch Biochem Biophys. 2004. PMID: 15001391

5

Functional role of residues in the helix B' region of cytochrome P450 2B1.

Honma W, Li W, Liu H, Scott EE, Halpert JR. Honma W, et al. Among authors: halpert jr. Arch Biochem Biophys. 2005 Mar 1;435(1):157-65. doi: 10.1016/j.abb.2004.12.014. Arch Biochem Biophys. 2005. PMID: 15680917

6

Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.

Kumar S, Liu H, Halpert JR. Kumar S, et al. Among authors: halpert jr. Drug Metab Dispos. 2006 Dec;34(12):1958-65. doi: 10.1124/dmd.106.012054. Epub 2006 Sep 20. Drug Metab Dispos. 2006. PMID: 16987939

7

Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.

Hernandez CE, Kumar S, Liu H, Halpert JR. Hernandez CE, et al. Among authors: halpert jr. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7. doi: 10.1016/j.abb.2006.08.024. Epub 2006 Sep 25. Arch Biochem Biophys. 2006. PMID: 17027909 Free PMC article.

8

Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.

Sun L, Chen CS, Waxman DJ, Liu H, Halpert JR, Kumar S. Sun L, et al. Among authors: halpert jr. Arch Biochem Biophys. 2007 Feb 15;458(2):167-74. doi: 10.1016/j.abb.2006.12.021. Epub 2007 Jan 8. Arch Biochem Biophys. 2007. PMID: 17254539 Free PMC article.

9

Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study.

Khan KK, Liu H, Halpert JR. Khan KK, et al. Among authors: halpert jr. Drug Metab Dispos. 2003 Apr;31(4):356-9. doi: 10.1124/dmd.31.4.356. Drug Metab Dispos. 2003. PMID: 12642459

10

Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.

Kumar S, Sun L, Liu H, Muralidhara BK, Halpert JR. Kumar S, et al. Among authors: halpert jr. Protein Eng Des Sel. 2006 Dec;19(12):547-54. doi: 10.1093/protein/gzl042. Epub 2006 Oct 18. Protein Eng Des Sel. 2006. PMID: 17050590

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