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Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans.
Gingis-Velitski S, Zetser A, Kaplan V, Ben-Zaken O, Cohen E, Levy-Adam F, Bashenko Y, Flugelman MY, Vlodavsky I, Ilan N. Gingis-Velitski S, et al. J Biol Chem. 2004 Oct 15;279(42):44084-92. doi: 10.1074/jbc.M402131200. Epub 2004 Jul 29. J Biol Chem. 2004. PMID: 15292202 Free article.
Heparanase induces Akt phosphorylation via a lipid raft receptor.
Ben-Zaken O, Gingis-Velitski S, Vlodavsky I, Ilan N. Ben-Zaken O, et al. Biochem Biophys Res Commun. 2007 Oct 5;361(4):829-34. doi: 10.1016/j.bbrc.2007.06.188. Epub 2007 Jul 24. Biochem Biophys Res Commun. 2007. PMID: 17689495 Free PMC article.
Low and high affinity receptors mediate cellular uptake of heparanase.
Ben-Zaken O, Shafat I, Gingis-Velitski S, Bangio H, Kelson IK, Alergand T, Amor Y, Maya RB, Vlodavsky I, Ilan N. Ben-Zaken O, et al. Int J Biochem Cell Biol. 2008;40(3):530-42. doi: 10.1016/j.biocel.2007.09.003. Epub 2007 Sep 29. Int J Biochem Cell Biol. 2008. PMID: 17981072 Free PMC article.
Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.
Alishekevitz D, Gingis-Velitski S, Kaidar-Person O, Gutter-Kapon L, Scherer SD, Raviv Z, Merquiol E, Ben-Nun Y, Miller V, Rachman-Tzemah C, Timaner M, Mumblat Y, Ilan N, Loven D, Hershkovitz D, Satchi-Fainaro R, Blum G, Sleeman JP, Vlodavsky I, Shaked Y. Alishekevitz D, et al. Among authors: gingis velitski s. Cell Rep. 2016 Oct 25;17(5):1344-1356. doi: 10.1016/j.celrep.2016.09.083. Cell Rep. 2016. PMID: 27783948 Free PMC article.
23 results