Wagenaar E - Search Results

1

Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.

Vlaming ML, Mohrmann K, Wagenaar E, de Waart DR, Elferink RP, Lagas JS, van Tellingen O, Vainchtein LD, Rosing H, Beijnen JH, Schellens JH, Schinkel AH. Vlaming ML, et al. Among authors: wagenaar e. J Pharmacol Exp Ther. 2006 Jul;318(1):319-27. doi: 10.1124/jpet.106.101774. Epub 2006 Apr 12. J Pharmacol Exp Ther. 2006. PMID: 16611851 Free article.

2

Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics.

Lagas JS, Vlaming ML, van Tellingen O, Wagenaar E, Jansen RS, Rosing H, Beijnen JH, Schinkel AH. Lagas JS, et al. Among authors: wagenaar e. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6125-32. doi: 10.1158/1078-0432.CCR-06-1352. Clin Cancer Res. 2006. PMID: 17062689

3

Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2).

Zimmermann C, van de Wetering K, van de Steeg E, Wagenaar E, Vens C, Schinkel AH. Zimmermann C, et al. Among authors: wagenaar e. Drug Metab Dispos. 2008 Apr;36(4):631-40. doi: 10.1124/dmd.107.019620. Epub 2008 Jan 7. Drug Metab Dispos. 2008. PMID: 18180270

4

Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.

Vlaming ML, Pala Z, van Esch A, Wagenaar E, van Tellingen O, de Waart DR, Oude Elferink RP, van de Wetering K, Schinkel AH. Vlaming ML, et al. Among authors: wagenaar e. Clin Cancer Res. 2008 Dec 15;14(24):8152-60. doi: 10.1158/1078-0432.CCR-08-1609. Clin Cancer Res. 2008. PMID: 19088030

5

Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo.

Vlaming ML, Pala Z, van Esch A, Wagenaar E, de Waart DR, van de Wetering K, van der Kruijssen CM, Oude Elferink RP, van Tellingen O, Schinkel AH. Vlaming ML, et al. Among authors: wagenaar e. Clin Cancer Res. 2009 May 1;15(9):3084-93. doi: 10.1158/1078-0432.CCR-08-2940. Epub 2009 Apr 21. Clin Cancer Res. 2009. PMID: 19383815

6

Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.

Vlaming ML, van Esch A, Pala Z, Wagenaar E, van de Wetering K, van Tellingen O, Schinkel AH. Vlaming ML, et al. Among authors: wagenaar e. Mol Cancer Ther. 2009 Dec;8(12):3350-9. doi: 10.1158/1535-7163.MCT-09-0668. Mol Cancer Ther. 2009. PMID: 19996279

7

P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide.

Lagas JS, Fan L, Wagenaar E, Vlaming ML, van Tellingen O, Beijnen JH, Schinkel AH. Lagas JS, et al. Among authors: wagenaar e. Clin Cancer Res. 2010 Jan 1;16(1):130-40. doi: 10.1158/1078-0432.CCR-09-1321. Epub 2009 Dec 22. Clin Cancer Res. 2010. PMID: 20028753

8

Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters.

Lagas JS, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH. Lagas JS, et al. Among authors: wagenaar e. Mol Pharmacol. 2010 Apr;77(4):687-94. doi: 10.1124/mol.109.062364. Epub 2010 Jan 19. Mol Pharmacol. 2010. PMID: 20086033

9

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.

Lagas JS, van Waterschoot RA, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH. Lagas JS, et al. Among authors: wagenaar e. Mol Cancer Ther. 2010 Feb;9(2):319-26. doi: 10.1158/1535-7163.MCT-09-0663. Epub 2010 Jan 26. Mol Cancer Ther. 2010. PMID: 20103600

10

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.

van Waterschoot RA, Lagas JS, Wagenaar E, Rosing H, Beijnen JH, Schinkel AH. van Waterschoot RA, et al. Among authors: wagenaar e. Int J Cancer. 2010 Dec 15;127(12):2959-64. doi: 10.1002/ijc.25279. Int J Cancer. 2010. PMID: 21351274

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