Hong L - Search Results

1

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.

Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: hong l. J Am Chem Soc. 2006 Apr 26;128(16):5310-1. doi: 10.1021/ja058636j. J Am Chem Soc. 2006. PMID: 16620080 Free PMC article.

2

Beta-secretase as a therapeutic target for inhibitor drugs.

Ghosh AK, Hong L, Tang J. Ghosh AK, et al. Among authors: hong l. Curr Med Chem. 2002 Jun;9(11):1135-44. doi: 10.2174/0929867023370149. Curr Med Chem. 2002. PMID: 12052177 Review.

3

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.

Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J. Hong L, et al. Biochemistry. 2002 Sep 10;41(36):10963-7. doi: 10.1021/bi026232n. Biochemistry. 2002. PMID: 12206667

4

Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.

Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT 3rd, Chang W. Tang J, et al. Among authors: hong l. J Mol Neurosci. 2003;20(3):299-304. doi: 10.1385/JMN:20:3:299. J Mol Neurosci. 2003. PMID: 14501012 Review.

5

Memapsin 2, a drug target for Alzheimer's disease.

Koelsch G, Turner RT 3rd, Hong L, Ghosh AK, Tang J. Koelsch G, et al. Among authors: hong l. Biochem Soc Symp. 2003;(70):213-20. doi: 10.1042/bss0700213. Biochem Soc Symp. 2003. PMID: 14587294 Review.

6

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).

Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: hong l. Bioorg Med Chem Lett. 2005 Jan 3;15(1):15-20. doi: 10.1016/j.bmcl.2004.10.084. Bioorg Med Chem Lett. 2005. PMID: 15582402

7

Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: hong l. J Med Chem. 2007 May 17;50(10):2399-407. doi: 10.1021/jm061338s. Epub 2007 Apr 14. J Med Chem. 2007. PMID: 17432843

8

Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality.

Ghosh AK, Bilcer G, Hong L, Koelsch G, Tang J. Ghosh AK, et al. Among authors: hong l. Curr Alzheimer Res. 2007 Sep;4(4):418-22. doi: 10.2174/156720507781788864. Curr Alzheimer Res. 2007. PMID: 17908045 Review.

9

Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J. Ghosh AK, et al. Among authors: hong l. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1031-6. doi: 10.1016/j.bmcl.2007.12.028. Epub 2008 Jan 3. Bioorg Med Chem Lett. 2008. PMID: 18180160 Free PMC article.

10

Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.

Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YF, Chumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: hong l. J Med Chem. 2009 Dec 10;52(23):7689-705. doi: 10.1021/jm900695w. J Med Chem. 2009. PMID: 19746963 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

3,879 results

Search Page

Filters