Hussain KA - Search Results

1

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.

Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: hussain ka. J Am Chem Soc. 2006 Apr 26;128(16):5310-1. doi: 10.1021/ja058636j. J Am Chem Soc. 2006. PMID: 16620080 Free PMC article.

2

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

Ghosh AK, Bilcer G, Harwood C, Kawahama R, Shin D, Hussain KA, Hong L, Loy JA, Nguyen C, Koelsch G, Ermolieff J, Tang J. Ghosh AK, et al. Among authors: hussain ka. J Med Chem. 2001 Aug 30;44(18):2865-8. doi: 10.1021/jm0101803. J Med Chem. 2001. PMID: 11520194

3

Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.

Ghosh AK, Swanson LM, Cho H, Leshchenko S, Hussain KA, Kay S, Walters DE, Koh Y, Mitsuya H. Ghosh AK, et al. Among authors: hussain ka. J Med Chem. 2005 May 19;48(10):3576-85. doi: 10.1021/jm050019i. J Med Chem. 2005. PMID: 15887965

4

Convenient synthesis of novel macrocyclic urethanes: alkoxycarbonylation of amines and ring-closing metathesis strategy.

Ghosh AK, Hussain KA. Ghosh AK, et al. Among authors: hussain ka. Tetrahedron Lett. 1998 Apr 2;39(14):1881-1884. doi: 10.1016/S0040-4039(98)00153-1. Tetrahedron Lett. 1998. PMID: 30383041 Free PMC article.

5

Structure-based design of non-peptide HIV protease inhibitors.

Ghosh AK, Shin D, Swanson L, Krishnan K, Cho H, Hussain KA, Walters DE, Holland L, Buthod J. Ghosh AK, et al. Among authors: hussain ka. Farmaco. 2001 Jan-Feb;56(1-2):29-32. doi: 10.1016/s0014-827x(01)01025-4. Farmaco. 2001. PMID: 11347961 Review.

6

Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease.

Ghosh AK, Pretzer E, Cho H, Hussain KA, Düzgüneş N. Ghosh AK, et al. Among authors: hussain ka. Antiviral Res. 2002 Apr;54(1):29-36. doi: 10.1016/s0166-3542(01)00209-1. Antiviral Res. 2002. PMID: 11888655

7

Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy.

Ghosh AK, Swanson LM, Liu C, Hussain KA, Cho H, Walters DE, Holland L, Buthod J. Ghosh AK, et al. Among authors: hussain ka. Bioorg Med Chem Lett. 2002 Aug 5;12(15):1993-6. doi: 10.1016/s0960-894x(02)00300-1. Bioorg Med Chem Lett. 2002. PMID: 12113826

8

Asymmetric Aldol Route to Hydroxyethylamine Isostere: Stereoselective Synthesis of the Core Unit of Saquinavir.

Ghosh AK, Hussain KA, Fidanze S. Ghosh AK, et al. Among authors: hussain ka. J Org Chem. 1997 Aug 22;62(17):6080-6082. doi: 10.1021/jo9706943. J Org Chem. 1997. PMID: 30504991 Free PMC article. No abstract available.

9

ESTER DERIVED TITANIUM ENOLATE ALDOL REACTION: HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF SYN- AND ANTI-ALDOLS.

Ghosh AK, Fidanze S, Onishi M, Hussain KA. Ghosh AK, et al. Among authors: hussain ka. Tetrahedron Lett. 1997 Oct 13;38(41):7171-7174. doi: 10.1016/S0040-4039(97)01765-6. Tetrahedron Lett. 1997. PMID: 30407471 Free PMC article.

10

Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

Ghosh AK, Kincaid JF, Cho W, Walters DE, Krishnan K, Hussain KA, Koo Y, Cho H, Rudall C, Holland L, Buthod J. Ghosh AK, et al. Among authors: hussain ka. Bioorg Med Chem Lett. 1998 Mar 17;8(6):687-90. doi: 10.1016/s0960-894x(98)00098-5. Bioorg Med Chem Lett. 1998. PMID: 9871583

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