Koelsch G - Search Results

1

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.

Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: koelsch g. J Am Chem Soc. 2006 Apr 26;128(16):5310-1. doi: 10.1021/ja058636j. J Am Chem Soc. 2006. PMID: 16620080 Free PMC article.

2

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.

Turner RT 3rd, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J. Turner RT 3rd, et al. Among authors: koelsch g. Biochemistry. 2002 Jul 9;41(27):8742-6. doi: 10.1021/bi025926t. Biochemistry. 2002. PMID: 12093293

3

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.

Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J. Hong L, et al. Among authors: koelsch g. Biochemistry. 2002 Sep 10;41(36):10963-7. doi: 10.1021/bi026232n. Biochemistry. 2002. PMID: 12206667

4

Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.

Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT 3rd, Chang W. Tang J, et al. Among authors: koelsch g. J Mol Neurosci. 2003;20(3):299-304. doi: 10.1385/JMN:20:3:299. J Mol Neurosci. 2003. PMID: 14501012 Review.

5

Memapsin 2, a drug target for Alzheimer's disease.

Koelsch G, Turner RT 3rd, Hong L, Ghosh AK, Tang J. Koelsch G, et al. Biochem Soc Symp. 2003;(70):213-20. doi: 10.1042/bss0700213. Biochem Soc Symp. 2003. PMID: 14587294 Review.

6

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).

Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: koelsch g. Bioorg Med Chem Lett. 2005 Jan 3;15(1):15-20. doi: 10.1016/j.bmcl.2004.10.084. Bioorg Med Chem Lett. 2005. PMID: 15582402

7

Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: koelsch g. J Med Chem. 2007 May 17;50(10):2399-407. doi: 10.1021/jm061338s. Epub 2007 Apr 14. J Med Chem. 2007. PMID: 17432843

8

Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality.

Ghosh AK, Bilcer G, Hong L, Koelsch G, Tang J. Ghosh AK, et al. Among authors: koelsch g. Curr Alzheimer Res. 2007 Sep;4(4):418-22. doi: 10.2174/156720507781788864. Curr Alzheimer Res. 2007. PMID: 17908045 Review.

9

Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J. Ghosh AK, et al. Among authors: koelsch g. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1031-6. doi: 10.1016/j.bmcl.2007.12.028. Epub 2008 Jan 3. Bioorg Med Chem Lett. 2008. PMID: 18180160 Free PMC article.

10

Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.

Ghosh AK, Brindisi M, Yen YC, Xu X, Huang X, Devasamudram T, Bilcer G, Lei H, Koelsch G, Mesecar AD, Tang J. Ghosh AK, et al. Among authors: koelsch g. Bioorg Med Chem Lett. 2015 Feb 1;25(3):668-72. doi: 10.1016/j.bmcl.2014.11.087. Epub 2014 Dec 6. Bioorg Med Chem Lett. 2015. PMID: 25537272 Free PMC article.

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