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Domain interdependence in the biosynthetic assembly of CFTR.
Cui L, Aleksandrov L, Chang XB, Hou YX, He L, Hegedus T, Gentzsch M, Aleksandrov A, Balch WE, Riordan JR. Cui L, et al. Among authors: hegedus t. J Mol Biol. 2007 Jan 26;365(4):981-94. doi: 10.1016/j.jmb.2006.10.086. Epub 2006 Nov 10. J Mol Biol. 2007. PMID: 17113596
Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating.
He L, Aleksandrov AA, Serohijos AW, Hegedus T, Aleksandrov LA, Cui L, Dokholyan NV, Riordan JR. He L, et al. Among authors: hegedus t. J Biol Chem. 2008 Sep 26;283(39):26383-90. doi: 10.1074/jbc.M803894200. Epub 2008 Jul 25. J Biol Chem. 2008. PMID: 18658148 Free PMC article.
A recently constructed computational model of the CFTR three-dimensional structure, supported by experimental data (Serohijos, A. W., Hegedus, T., Aleksandrov, A. A., He, L., Cui, L., Dokholyan, N. V., and Riordan, J. R. (2008) Proc. ...
A recently constructed computational model of the CFTR three-dimensional structure, supported by experimental data (Serohijos, A. W., Heg …
Discovering the chloride pathway in the CFTR channel.
Farkas B, Tordai H, Padányi R, Tordai A, Gera J, Paragi G, Hegedűs T. Farkas B, et al. Among authors: hegedus t. Cell Mol Life Sci. 2020 Feb;77(4):765-778. doi: 10.1007/s00018-019-03211-4. Epub 2019 Jul 20. Cell Mol Life Sci. 2020. PMID: 31327045 Free PMC article.
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.
Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Veit G, et al. Among authors: hegedus t. Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889. Sci Transl Med. 2014. PMID: 25101887 Free PMC article.
81 results