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A single-dose comparison of the acute effects between the new somatostatin analog SOM230 and octreotide in acromegalic patients.
van der Hoek J, de Herder WW, Feelders RA, van der Lely AJ, Uitterlinden P, Boerlin V, Bruns C, Poon KW, Lewis I, Weckbecker G, Krahnke T, Hofland LJ, Lamberts SW. van der Hoek J, et al. Among authors: van der lely aj. J Clin Endocrinol Metab. 2004 Feb;89(2):638-45. doi: 10.1210/jc.2003-031052. J Clin Endocrinol Metab. 2004. PMID: 14764775 Free article. Clinical Trial.
The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro.
Hofland LJ, van der Hoek J, van Koetsveld PM, de Herder WW, Waaijers M, Sprij-Mooij D, Bruns C, Weckbecker G, Feelders R, van der Lely AJ, Beckers A, Lamberts SW. Hofland LJ, et al. Among authors: van koetsveld pm, van der lely aj, van der hoek j. J Clin Endocrinol Metab. 2004 Apr;89(4):1577-85. doi: 10.1210/jc.2003-031344. J Clin Endocrinol Metab. 2004. PMID: 15070915 Free article.
Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells.
van der Hoek J, Waaijers M, van Koetsveld PM, Sprij-Mooij D, Feelders RA, Schmid HA, Schoeffter P, Hoyer D, Cervia D, Taylor JE, Culler MD, Lamberts SW, Hofland LJ. van der Hoek J, et al. Among authors: van koetsveld pm. Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E278-87. doi: 10.1152/ajpendo.00004.2005. Epub 2005 Mar 15. Am J Physiol Endocrinol Metab. 2005. PMID: 15769796 Free article.
The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5.
Hofland LJ, van der Hoek J, Feelders R, van Aken MO, van Koetsveld PM, Waaijers M, Sprij-Mooij D, Bruns C, Weckbecker G, de Herder WW, Beckers A, Lamberts SW. Hofland LJ, et al. Among authors: van koetsveld pm, van aken mo, van der hoek j. Eur J Endocrinol. 2005 Apr;152(4):645-54. doi: 10.1530/eje.1.01876. Eur J Endocrinol. 2005. PMID: 15817922 Free article.
The somatostatin analogue SOM230, compared with octreotide, induces differential effects in several metabolic pathways in acromegalic patients.
van der Hoek J, van der Lelij AJ, Feelders RA, de Herder WW, Uitterlinden P, Poon KW, Boerlin V, Lewis I, Krahnke T, Hofland LJ, Lamberts SW. van der Hoek J, et al. Among authors: van der lelij aj. Clin Endocrinol (Oxf). 2005 Aug;63(2):176-84. doi: 10.1111/j.1365-2265.2005.02322.x. Clin Endocrinol (Oxf). 2005. PMID: 16060911 Clinical Trial.
New insights on SOM230, a universal somatostatin receptor ligand.
Boerlin V, van der Hoek J, Beglinger Ch, Poon KW, Hartmann S, Dutreix C, Kovarik JM, Bruns Ch, Weckbecker G, Lewis I, Schnieper P, Hofland LJ, Lamberts SW. Boerlin V, et al. Among authors: van der hoek j. J Endocrinol Invest. 2003;26(8 Suppl):14-6. J Endocrinol Invest. 2003. PMID: 15233205 Clinical Trial. No abstract available.
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