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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.
Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR Jr, Sacchettini JC, Fidock DA. Kuo MR, et al. Among authors: morbidoni hr. J Biol Chem. 2003 Jun 6;278(23):20851-9. doi: 10.1074/jbc.M211968200. Epub 2003 Feb 26. J Biol Chem. 2003. PMID: 12606558 Free article.
A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone.
Grzegorzewicz AE, Korduláková J, Jones V, Born SE, Belardinelli JM, Vaquié A, Gundi VA, Madacki J, Slama N, Laval F, Vaubourgeix J, Crew RM, Gicquel B, Daffé M, Morbidoni HR, Brennan PJ, Quémard A, McNeil MR, Jackson M. Grzegorzewicz AE, et al. Among authors: morbidoni hr. J Biol Chem. 2012 Nov 9;287(46):38434-41. doi: 10.1074/jbc.M112.400994. Epub 2012 Sep 21. J Biol Chem. 2012. PMID: 23002234 Free PMC article.
Deletion of MSMEG_1350 in Mycobacterium smegmatis causes loss of epoxy-mycolic acids, fitness alteration at low temperature and resistance to a set of mycobacteriophages.
Di Capua CB, Belardinelli JM, Buchieri MV, Bortolotti A, Franceschelli JJ, Morbidoni HR. Di Capua CB, et al. Among authors: morbidoni hr. Microbiology (Reading). 2018 Dec;164(12):1567-1582. doi: 10.1099/mic.0.000734. Epub 2018 Oct 12. Microbiology (Reading). 2018. PMID: 30311878 Free article.
Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives.
Ghiano DG, de la Iglesia A, Liu N, Tonge PJ, Morbidoni HR, Labadie GR. Ghiano DG, et al. Among authors: morbidoni hr. Eur J Med Chem. 2017 Jan 5;125:842-852. doi: 10.1016/j.ejmech.2016.09.086. Epub 2016 Sep 28. Eur J Med Chem. 2017. PMID: 27750201 Free PMC article.
50 results