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Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).
Ghosh S, Elder A, Guo J, Mani U, Patane M, Carson K, Ye Q, Bennett R, Chi S, Jenkins T, Guan B, Kolbeck R, Smith S, Zhang C, LaRosa G, Jaffee B, Yang H, Eddy P, Lu C, Uttamsingh V, Horlick R, Harriman G, Flynn D. Ghosh S, et al. Among authors: horlick r. J Med Chem. 2006 May 4;49(9):2669-72. doi: 10.1021/jm050965z. J Med Chem. 2006. PMID: 16640325
Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model.
Vos TJ, Caracoti A, Che JL, Dai M, Farrer CA, Forsyth NE, Drabic SV, Horlick RA, Lamppu D, Yowe DL, Balani S, Li P, Zeng H, Joseph IB, Rodriguez LE, Maguire MP, Patane MA, Claiborne CF. Vos TJ, et al. J Med Chem. 2004 Mar 25;47(7):1602-4. doi: 10.1021/jm034244g. J Med Chem. 2004. PMID: 15027849
2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors.
Ho KK, Appell KC, Baldwin JJ, Bohnstedt AC, Dong G, Guo T, Horlick R, Islam KR, Kultgen SG, Masterson CM, McDonald E, McMillan K, Morphy JR, Rankovic Z, Sundaram H, Webb M. Ho KK, et al. Among authors: horlick r. Bioorg Med Chem Lett. 2004 Jan 19;14(2):545-8. doi: 10.1016/j.bmcl.2003.09.080. Bioorg Med Chem Lett. 2004. PMID: 14698200
Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand.
Willy PJ, Murray IR, Qian J, Busch BB, Stevens WC Jr, Martin R, Mohan R, Zhou S, Ordentlich P, Wei P, Sapp DW, Horlick RA, Heyman RA, Schulman IG. Willy PJ, et al. Among authors: horlick ra. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7. doi: 10.1073/pnas.0401420101. Epub 2004 Jun 7. Proc Natl Acad Sci U S A. 2004. PMID: 15184675 Free PMC article.
Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation.
Bowers PM, Neben TY, Tomlinson GL, Dalton JL, Altobell L, Zhang X, Macomber JL, Wu BF, Toobian RM, McConnell AD, Verdino P, Chau B, Horlick RA, King DJ. Bowers PM, et al. Among authors: horlick ra. J Biol Chem. 2013 Mar 15;288(11):7688-7696. doi: 10.1074/jbc.M112.445502. Epub 2013 Jan 25. J Biol Chem. 2013. PMID: 23355464 Free PMC article.
Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies.
Bowers PM, Horlick RA, Neben TY, Toobian RM, Tomlinson GL, Dalton JL, Jones HA, Chen A, Altobell L 3rd, Zhang X, Macomber JL, Krapf IP, Wu BF, McConnell A, Chau B, Holland T, Berkebile AD, Neben SS, Boyle WJ, King DJ. Bowers PM, et al. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20455-60. doi: 10.1073/pnas.1114010108. Epub 2011 Dec 7. Proc Natl Acad Sci U S A. 2011. PMID: 22158898 Free PMC article.
39 results