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Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).
Ghosh S, Elder A, Guo J, Mani U, Patane M, Carson K, Ye Q, Bennett R, Chi S, Jenkins T, Guan B, Kolbeck R, Smith S, Zhang C, LaRosa G, Jaffee B, Yang H, Eddy P, Lu C, Uttamsingh V, Horlick R, Harriman G, Flynn D. Ghosh S, et al. Among authors: zhang c. J Med Chem. 2006 May 4;49(9):2669-72. doi: 10.1021/jm050965z. J Med Chem. 2006. PMID: 16640325
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice.
Wang H, Wu Z, Cui D, Bian L, Zheng Z, Zhu J, Geng H, Sun Z, Pan Y, Shi Y, Yi Q, Song Z, Li Y, Shen K, Li Y, Shen W, Yan H, Hao R, Sun M, Zhang S, Zhang C, Jin H, Zhai B. Wang H, et al. Among authors: zhang c. Sci Transl Med. 2025 Jan 22;17(782):eadl6432. doi: 10.1126/scitranslmed.adl6432. Epub 2025 Jan 22. Sci Transl Med. 2025. PMID: 39841806
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