Niemi R - Search Results

1

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide.

Parkkari T, Savinainen JR, Raitio KH, Saario SM, Matilainen L, Sirviö T, Laitinen JT, Nevalainen T, Niemi R, Järvinen T. Parkkari T, et al. Among authors: niemi r. Bioorg Med Chem. 2006 Aug 1;14(15):5252-8. doi: 10.1016/j.bmc.2006.03.051. Epub 2006 Apr 27. Bioorg Med Chem. 2006. PMID: 16644227

2

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.

Savinainen JR, Saario SM, Niemi R, Järvinen T, Laitinen JT. Savinainen JR, et al. Among authors: niemi r. Br J Pharmacol. 2003 Dec;140(8):1451-9. doi: 10.1038/sj.bjp.0705577. Epub 2003 Nov 17. Br J Pharmacol. 2003. PMID: 14623770 Free PMC article.

3

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.

Saario SM, Savinainen JR, Laitinen JT, Järvinen T, Niemi R. Saario SM, et al. Among authors: niemi r. Biochem Pharmacol. 2004 Apr 1;67(7):1381-7. doi: 10.1016/j.bcp.2003.12.003. Biochem Pharmacol. 2004. PMID: 15013854

4

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes.

Saario SM, Salo OM, Nevalainen T, Poso A, Laitinen JT, Järvinen T, Niemi R. Saario SM, et al. Among authors: niemi r. Chem Biol. 2005 Jun;12(6):649-56. doi: 10.1016/j.chembiol.2005.04.013. Chem Biol. 2005. PMID: 15975510

5

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether.

Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T. Juntunen J, et al. Among authors: niemi r. J Med Chem. 2003 Nov 6;46(23):5083-6. doi: 10.1021/jm030877j. J Med Chem. 2003. PMID: 14584958

6

Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide.

Juntunen J, Huuskonen J, Laine K, Niemi R, Taipale H, Nevalainen T, Pate DW, Järvinen T. Juntunen J, et al. Among authors: niemi r. Eur J Pharm Sci. 2003 May;19(1):37-43. doi: 10.1016/s0928-0987(03)00044-7. Eur J Pharm Sci. 2003. PMID: 12729860

7

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate.

Ahlmark M, Vepsäläinen J, Taipale H, Niemi R, Järvinen T. Ahlmark M, et al. Among authors: niemi r. J Med Chem. 1999 Apr 22;42(8):1473-6. doi: 10.1021/jm9810809. J Med Chem. 1999. PMID: 10212134

8

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid.

Niemi R, Vepsäläinen J, Taipale H and, Järvinen T. Niemi R, et al. J Med Chem. 1999 Dec 2;42(24):5053-8. doi: 10.1021/jm991109o. J Med Chem. 1999. PMID: 10585214

9

Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs.

Niemi R, Huuskonen J, Laine K, Järvinen T. Niemi R, et al. Int J Pharm. 2005 May 13;295(1-2):121-7. doi: 10.1016/j.ijpharm.2005.02.002. Int J Pharm. 2005. PMID: 15847997

10

In-vitro corneal permeation of cannabinoids and their water-soluble phosphate ester prodrugs.

Juntunen J, Järvinen T, Niemi R. Juntunen J, et al. Among authors: niemi r. J Pharm Pharmacol. 2005 Sep;57(9):1153-7. doi: 10.1211/jpp.57.9.0009. J Pharm Pharmacol. 2005. PMID: 16105235

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