Takai H - Search Results

1

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.

Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX. Cao L, et al. Among authors: takai h. EMBO J. 2006 May 17;25(10):2167-77. doi: 10.1038/sj.emboj.7601115. Epub 2006 May 4. EMBO J. 2006. PMID: 16675955 Free PMC article.

2

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.

Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, Anderson CW, Appella E, Nakanishi M, Suzuki H, Nagashima K, Sawa H, Ikeda K, Motoyama N. Takai H, et al. EMBO J. 2002 Oct 1;21(19):5195-205. doi: 10.1093/emboj/cdf506. EMBO J. 2002. PMID: 12356735 Free PMC article.

3

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.

Takai H, Tominaga K, Motoyama N, Minamishima YA, Nagahama H, Tsukiyama T, Ikeda K, Nakayama K, Nakanishi M, Nakayama K. Takai H, et al. Genes Dev. 2000 Jun 15;14(12):1439-47. Genes Dev. 2000. PMID: 10859163 Free PMC article.

4

Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.

Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T. Silverman J, et al. Among authors: takai h. Genes Dev. 2004 Sep 1;18(17):2108-19. doi: 10.1101/gad.1216004. Genes Dev. 2004. PMID: 15342490 Free PMC article.

5

Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.

Kobayashi Y, Watanabe M, Okada Y, Sawa H, Takai H, Nakanishi M, Kawase Y, Suzuki H, Nagashima K, Ikeda K, Motoyama N. Kobayashi Y, et al. Among authors: takai h. Mol Cell Biol. 2002 Apr;22(8):2769-76. doi: 10.1128/MCB.22.8.2769-2776.2002. Mol Cell Biol. 2002. PMID: 11909969 Free PMC article.

6

Tel2 regulates the stability of PI3K-related protein kinases.

Takai H, Wang RC, Takai KK, Yang H, de Lange T. Takai H, et al. Among authors: takai kk. Cell. 2007 Dec 28;131(7):1248-59. doi: 10.1016/j.cell.2007.10.052. Cell. 2007. PMID: 18160036 Free article.

7

Targeted deletion reveals an essential function for the telomere length regulator Trf1.

Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T, de Lange T. Karlseder J, et al. Among authors: takai h. Mol Cell Biol. 2003 Sep;23(18):6533-41. doi: 10.1128/MCB.23.18.6533-6541.2003. Mol Cell Biol. 2003. PMID: 12944479 Free PMC article.

8

A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus.

Takai H, Jenkinson E, Kabir S, Babul-Hirji R, Najm-Tehrani N, Chitayat DA, Crow YJ, de Lange T. Takai H, et al. Genes Dev. 2016 Apr 1;30(7):812-26. doi: 10.1101/gad.276873.115. Epub 2016 Mar 24. Genes Dev. 2016. PMID: 27013236 Free PMC article.

9

DNA damage foci at dysfunctional telomeres.

Takai H, Smogorzewska A, de Lange T. Takai H, et al. Curr Biol. 2003 Sep 2;13(17):1549-56. doi: 10.1016/s0960-9822(03)00542-6. Curr Biol. 2003. PMID: 12956959 Free article.

10

Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.

Wu P, Takai H, de Lange T. Wu P, et al. Among authors: takai h. Cell. 2012 Jul 6;150(1):39-52. doi: 10.1016/j.cell.2012.05.026. Epub 2012 Jun 28. Cell. 2012. PMID: 22748632 Free PMC article.

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