Kast P - Search Results

1

Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved.

Krengel U, Dey R, Sasso S, Okvist M, Ramakrishnan C, Kast P. Krengel U, et al. Among authors: kast p. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt 5):441-5. doi: 10.1107/S1744309106012036. Epub 2006 Apr 12. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16682771 Free PMC article.

2

A strategically positioned cation is crucial for efficient catalysis by chorismate mutase.

Kast P, Grisostomi C, Chen IA, Li S, Krengel U, Xue Y, Hilvert D. Kast P, et al. J Biol Chem. 2000 Nov 24;275(47):36832-8. doi: 10.1074/jbc.M006351200. J Biol Chem. 2000. PMID: 10960481 Free article.

3

Characterization of the secreted chorismate mutase from the pathogen Mycobacterium tuberculosis.

Sasso S, Ramakrishnan C, Gamper M, Hilvert D, Kast P. Sasso S, et al. Among authors: kast p. FEBS J. 2005 Jan;272(2):375-89. doi: 10.1111/j.1742-4658.2004.04478.x. FEBS J. 2005. PMID: 15654876 Free article.

4

Mechanistic insights into the isochorismate pyruvate lyase activity of the catalytically promiscuous PchB from combinatorial mutagenesis and selection.

Künzler DE, Sasso S, Gamper M, Hilvert D, Kast P. Künzler DE, et al. Among authors: kast p. J Biol Chem. 2005 Sep 23;280(38):32827-34. doi: 10.1074/jbc.M506883200. Epub 2005 Jul 21. J Biol Chem. 2005. PMID: 16036918 Free article.

5

1.6 A crystal structure of the secreted chorismate mutase from Mycobacterium tuberculosis: novel fold topology revealed.

Okvist M, Dey R, Sasso S, Grahn E, Kast P, Krengel U. Okvist M, et al. Among authors: kast p. J Mol Biol. 2006 Apr 14;357(5):1483-99. doi: 10.1016/j.jmb.2006.01.069. Epub 2006 Feb 6. J Mol Biol. 2006. PMID: 16499927

6

Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.

Sasso S, Okvist M, Roderer K, Gamper M, Codoni G, Krengel U, Kast P. Sasso S, et al. Among authors: kast p. EMBO J. 2009 Jul 22;28(14):2128-42. doi: 10.1038/emboj.2009.165. Epub 2009 Jun 25. EMBO J. 2009. PMID: 19556970 Free PMC article.

7

A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis.

Okvist M, Sasso S, Roderer K, Kast P, Krengel U. Okvist M, et al. Among authors: kast p. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):1048-52. doi: 10.1107/S1744309109035878. Epub 2009 Sep 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19851019 Free PMC article.

8

When inhibitors do not inhibit: critical evaluation of rational drug design targeting chorismate mutase from Mycobacterium tuberculosis.

Munack S, Leroux V, Roderer K, Ökvist M, van Eerde A, Gundersen LL, Krengel U, Kast P. Munack S, et al. Among authors: kast p. Chem Biodivers. 2012 Nov;9(11):2507-27. doi: 10.1002/cbdv.201200322. Chem Biodivers. 2012. PMID: 23161632

9

Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.

Burschowsky D, van Eerde A, Ökvist M, Kienhöfer A, Kast P, Hilvert D, Krengel U. Burschowsky D, et al. Among authors: kast p. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17516-21. doi: 10.1073/pnas.1408512111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422475 Free PMC article.

10

Functional mapping of protein-protein interactions in an enzyme complex by directed evolution.

Roderer K, Neuenschwander M, Codoni G, Sasso S, Gamper M, Kast P. Roderer K, et al. Among authors: kast p. PLoS One. 2014 Dec 31;9(12):e116234. doi: 10.1371/journal.pone.0116234. eCollection 2014. PLoS One. 2014. PMID: 25551646 Free PMC article.

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