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The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.
Leoni F, Zaliani A, Bertolini G, Porro G, Pagani P, Pozzi P, Donà G, Fossati G, Sozzani S, Azam T, Bufler P, Fantuzzi G, Goncharov I, Kim SH, Pomerantz BJ, Reznikov LL, Siegmund B, Dinarello CA, Mascagni P. Leoni F, et al. Among authors: dinarello ca. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2995-3000. doi: 10.1073/pnas.052702999. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867742 Free PMC article.
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.
Reddy P, Sun Y, Toubai T, Duran-Struuck R, Clouthier SG, Weisiger E, Maeda Y, Tawara I, Krijanovski O, Gatza E, Liu C, Malter C, Mascagni P, Dinarello CA, Ferrara JL. Reddy P, et al. Among authors: dinarello ca. J Clin Invest. 2008 Jul;118(7):2562-73. doi: 10.1172/JCI34712. J Clin Invest. 2008. PMID: 18568076 Free PMC article.
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, van der Meer JH, van de Veerdonk FL, Ferwerda G, Heinhuis B, Devesa I, Funk CJ, Mason RJ, Kullberg BJ, Rubartelli A, van der Meer JW, Dinarello CA. Netea MG, et al. Among authors: dinarello ca. Blood. 2009 Mar 5;113(10):2324-35. doi: 10.1182/blood-2008-03-146720. Epub 2008 Dec 22. Blood. 2009. PMID: 19104081 Free PMC article.
The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro.
Matalon S, Palmer BE, Nold MF, Furlan A, Kassu A, Fossati G, Mascagni P, Dinarello CA. Matalon S, et al. Among authors: dinarello ca. J Acquir Immune Defic Syndr. 2010 May 1;54(1):1-9. doi: 10.1097/QAI.0b013e3181d3dca3. J Acquir Immune Defic Syndr. 2010. PMID: 20300007 Free PMC article.
1,093 results