Stathis MJ - Search Results

1

Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain.

Majer P, Hin B, Stoermer D, Adams J, Xu W, Duvall BR, Delahanty G, Liu Q, Stathis MJ, Wozniak KM, Slusher BS, Tsukamoto T. Majer P, et al. Among authors: stathis mj. J Med Chem. 2006 May 18;49(10):2876-85. doi: 10.1021/jm051019l. J Med Chem. 2006. PMID: 16686531

2

The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II.

Grella B, Adams J, Berry JF, Delahanty G, Ferraris DV, Majer P, Ni C, Shukla K, Shuler SA, Slusher BS, Stathis M, Tsukamoto T. Grella B, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7222-5. doi: 10.1016/j.bmcl.2010.10.109. Epub 2010 Oct 26. Bioorg Med Chem Lett. 2010. PMID: 21074428

3

Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds.

Stoermer D, Vitharana D, Hin N, Delahanty G, Duvall B, Ferraris DV, Grella BS, Hoover R, Rojas C, Shanholtz MK, Smith KP, Stathis M, Wu Y, Wozniak KM, Slusher BS, Tsukamoto T. Stoermer D, et al. J Med Chem. 2012 Jun 28;55(12):5922-32. doi: 10.1021/jm300488m. Epub 2012 Jun 12. J Med Chem. 2012. PMID: 22642259

4

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

Shukla K, Ferraris DV, Thomas AG, Stathis M, Duvall B, Delahanty G, Alt J, Rais R, Rojas C, Gao P, Xiang Y, Dang CV, Slusher BS, Tsukamoto T. Shukla K, et al. J Med Chem. 2012 Dec 13;55(23):10551-63. doi: 10.1021/jm301191p. Epub 2012 Nov 30. J Med Chem. 2012. PMID: 23151085 Free PMC article.

5

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration.

Rais R, Wozniak K, Wu Y, Niwa M, Stathis M, Alt J, Giroux M, Sawa A, Rojas C, Slusher BS. Rais R, et al. PLoS One. 2015 Jul 7;10(7):e0131861. doi: 10.1371/journal.pone.0131861. eCollection 2015. PLoS One. 2015. PMID: 26151906 Free PMC article.

6

Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold.

Zimmermann SC, Wolf EF, Luu A, Thomas AG, Stathis M, Poore B, Nguyen C, Le A, Rojas C, Slusher BS, Tsukamoto T. Zimmermann SC, et al. ACS Med Chem Lett. 2016 Mar 13;7(5):520-4. doi: 10.1021/acsmedchemlett.6b00060. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27200176 Free PMC article.

7

Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies.

Rojas C, Stathis M, Polydefkis M, Rudek MA, Zhao M, Ebenezer GJ, Slusher BS. Rojas C, et al. J Transl Med. 2011 Mar 9;9:27. doi: 10.1186/1479-5876-9-27. J Transl Med. 2011. PMID: 21388540 Free PMC article.

8

Glutamate carboxypeptidase II is not an amyloid peptide-degrading enzyme.

Alt J, Stathis M, Rojas C, Slusher B. Alt J, et al. FASEB J. 2013 Jul;27(7):2620-5. doi: 10.1096/fj.12-225102. Epub 2013 Mar 23. FASEB J. 2013. PMID: 23525278 Free PMC article.

9

Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects.

Stathis M, Pietra C, Rojas C, Slusher BS. Stathis M, et al. Eur J Pharmacol. 2012 Aug 15;689(1-3):25-30. doi: 10.1016/j.ejphar.2012.05.037. Epub 2012 Jun 7. Eur J Pharmacol. 2012. PMID: 22683863

10

Synthesis and biological evaluation of low molecular weight fluorescent imaging agents for the prostate-specific membrane antigen.

Chen Y, Pullambhatla M, Banerjee SR, Byun Y, Stathis M, Rojas C, Slusher BS, Mease RC, Pomper MG. Chen Y, et al. Bioconjug Chem. 2012 Dec 19;23(12):2377-85. doi: 10.1021/bc3003919. Epub 2012 Dec 4. Bioconjug Chem. 2012. PMID: 23157641 Free PMC article.

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