Hawes BE - Search Results

1

Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists.

Wu WL, Burnett DA, Spring R, Qiang L, Sasikumar TK, Domalski MS, Greenlee WJ, O'Neill K, Hawes BE. Wu WL, et al. Among authors: hawes be. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3668-73. doi: 10.1016/j.bmcl.2006.04.061. Epub 2006 May 11. Bioorg Med Chem Lett. 2006. PMID: 16690312

2

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, Spar B, Kowalski TJ, Farley C, Cook J, van Heek M, Weig B, O'neill K, Graziano M, Hawes B. Palani A, et al. J Med Chem. 2005 Jul 28;48(15):4746-9. doi: 10.1021/jm0503852. J Med Chem. 2005. PMID: 16033253

3

Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, O'Neill K, Hawes B. Palani A, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5234-6. doi: 10.1016/j.bmcl.2005.08.043. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202583

4

Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: impacting hERG liability via aryl modifications.

McBriar MD, Guzik H, Shapiro S, Xu R, Paruchova J, Clader JW, O'neill K, Hawes B, Sorota S, Margulis M, Tucker K, Weston DJ, Cox K. McBriar MD, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4262-5. doi: 10.1016/j.bmcl.2006.05.069. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16753297

5

Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes.

Xia Y, Chackalamannil S, Greenlee WJ, Jayne C, Neustadt B, Stamford A, Vaccaro H, Xu XL, Baker H, O'Neill K, Woods M, Hawes B, Kowalski T. Xia Y, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3290-6. doi: 10.1016/j.bmcl.2011.04.035. Epub 2011 Apr 14. Bioorg Med Chem Lett. 2011. PMID: 21536438

6

Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis.

Su J, McKittrick BA, Tang H, Czarniecki M, Greenlee WJ, Hawes BE, O'Neill K. Su J, et al. Among authors: hawes be. Bioorg Med Chem. 2005 Mar 1;13(5):1829-36. doi: 10.1016/j.bmc.2004.11.046. Bioorg Med Chem. 2005. PMID: 15698800

7

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B. McBriar MD, et al. Among authors: hawes be. J Med Chem. 2005 Apr 7;48(7):2274-7. doi: 10.1021/jm049035q. J Med Chem. 2005. PMID: 15801820

8

Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.

Xu R, Li S, Paruchova J, McBriar MD, Guzik H, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B, Weston DJ. Xu R, et al. Among authors: hawes be. Bioorg Med Chem. 2006 May 15;14(10):3285-99. doi: 10.1016/j.bmc.2005.12.046. Epub 2006 Jan 26. Bioorg Med Chem. 2006. PMID: 16442800

9

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J. McBriar MD, et al. Among authors: hawes be. J Med Chem. 2006 Apr 6;49(7):2294-310. doi: 10.1021/jm050886n. J Med Chem. 2006. PMID: 16570926

10

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

Wu WL, Burnett DA, Caplen MA, Domalski MS, Bennett C, Greenlee WJ, Hawes BE, O'Neill K, Weig B, Weston D, Spar B, Kowalski T. Wu WL, et al. Among authors: hawes be. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3674-8. doi: 10.1016/j.bmcl.2006.04.062. Epub 2006 May 11. Bioorg Med Chem Lett. 2006. PMID: 16690315

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