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Page 1
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.
Harper S, Avolio S, Pacini B, Di Filippo M, Altamura S, Tomei L, Paonessa G, Di Marco S, Carfi A, Giuliano C, Padron J, Bonelli F, Migliaccio G, De Francesco R, Laufer R, Rowley M, Narjes F. Harper S, et al. Among authors: di marco s, di filippo m. J Med Chem. 2005 Jul 14;48(14):4547-57. doi: 10.1021/jm050056+. J Med Chem. 2005. PMID: 15999993
2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.
Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De Francesco R, Altamura S, Matassa VG, Narjes F. Koch U, et al. Among authors: di filippo m. J Med Chem. 2006 Mar 9;49(5):1693-705. doi: 10.1021/jm051064t. J Med Chem. 2006. PMID: 16509585
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.
Harper S, McCauley JA, Rudd MT, Ferrara M, DiFilippo M, Crescenzi B, Koch U, Petrocchi A, Holloway MK, Butcher JW, Romano JJ, Bush KJ, Gilbert KF, McIntyre CJ, Nguyen KT, Nizi E, Carroll SS, Ludmerer SW, Burlein C, DiMuzio JM, Graham DJ, McHale CM, Stahlhut MW, Olsen DB, Monteagudo E, Cianetti S, Giuliano C, Pucci V, Trainor N, Fandozzi CM, Rowley M, Coleman PJ, Vacca JP, Summa V, Liverton NJ. Harper S, et al. ACS Med Chem Lett. 2012 Mar 2;3(4):332-6. doi: 10.1021/ml300017p. eCollection 2012 Apr 12. ACS Med Chem Lett. 2012. PMID: 24900473 Free PMC article.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Summa V, Ludmerer SW, McCauley JA, Fandozzi C, Burlein C, Claudio G, Coleman PJ, Dimuzio JM, Ferrara M, Di Filippo M, Gates AT, Graham DJ, Harper S, Hazuda DJ, Huang Q, McHale C, Monteagudo E, Pucci V, Rowley M, Rudd MT, Soriano A, Stahlhut MW, Vacca JP, Olsen DB, Liverton NJ, Carroll SS. Summa V, et al. Among authors: di filippo m. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7. doi: 10.1128/AAC.00324-12. Epub 2012 May 21. Antimicrob Agents Chemother. 2012. PMID: 22615282 Free PMC article.
P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.
Rudd MT, Butcher JW, Nguyen KT, McIntyre CJ, Romano JJ, Gilbert KF, Bush KJ, Liverton NJ, Holloway MK, Harper S, Ferrara M, DiFilippo M, Summa V, Swestock J, Fritzen J, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q, McClain S, McHale C, Stahlhut MW, Black S, Chase R, Soriano A, Fandozzi CM, Taylor A, Trainor N, Olsen DB, Coleman PJ, Ludmerer SW, McCauley JA. Rudd MT, et al. ChemMedChem. 2015 Apr;10(4):727-35. doi: 10.1002/cmdc.201402558. Epub 2015 Mar 10. ChemMedChem. 2015. PMID: 25759009
Conformational Antibodies to Proteolipid Protein-1 and Its Peripheral Isoform DM20 in Patients With CNS Autoimmune Demyelinating Disorders.
Masciocchi S, Businaro P, Greco G, Scaranzin S, Malvaso A, Morandi C, Zardini E, Risi M, Vegezzi E, Diamanti L, Bini P, Siquilini S, Giannoccaro MP, Morelli L, Liguori R, Patti F, De Giuli V, Portaccio E, Zanetta C, Bergamoni S, Simone AM, Lanzillo R, Bruno G, Gallo A, Bisecco A, Di Filippo M, Pauri F, Toriello A, Barone P, Tazza F, Bucello S, Banfi P, Fabris M, Volonghi I, Raciti L, Vigliani MC, Bocci T, Paoletti M, Colombo E, Filippi M, Pichiecchio A, Marchioni E, Franciotta D, Gastaldi M; Neuroimmunology platform study group (PNI). Masciocchi S, et al. Among authors: di filippo m. Neurol Neuroimmunol Neuroinflamm. 2025 Mar;12(2):e200359. doi: 10.1212/NXI.0000000000200359. Epub 2025 Jan 17. Neurol Neuroimmunol Neuroinflamm. 2025. PMID: 39823554 Free article.
Effectiveness, safety, and impact on multiple sclerosis course of anti-CGRP monoclonal antibodies.
Nociti V, Romozzi M, Annovazzi P, Fantozzi R, Tortorella C, Vercellino M, Iannone LF, De Luca G, Tomassini V, Di Filippo M, Lorefice L, Maniscalco GT, Paolicelli D, Pinardi F, Ronzoni M, Solaro CM, Gasperini C, Calabresi P, Vollono C, Cocco E. Nociti V, et al. Among authors: di filippo m. J Neurol Sci. 2025 Jan 8;469:123392. doi: 10.1016/j.jns.2025.123392. Online ahead of print. J Neurol Sci. 2025. PMID: 39808882
Effect of autoimmune comorbidities on multiple sclerosis course: An observational multicenter study.
Nociti V, Romozzi M, Prosperini L, Clerici VT, Ragonese P, Gallo A, Maniscalco GT, Di Filippo M, Buscarinu MC, Lorefice L, Pinardi F, Gajofatto A, Cavalla P, Buttari F, Ferraro D, De Luca G, Solaro C, Gasperini C, Cocco E; RIREMS Study Group. Nociti V, et al. Among authors: di filippo m. Eur J Neurol. 2025 Jan;32(1):e70019. doi: 10.1111/ene.70019. Eur J Neurol. 2025. PMID: 39722573 Free PMC article.
304 results