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A robust small-molecule microarray platform for screening cell lysates.
Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. Bradner JE, et al. Chem Biol. 2006 May;13(5):493-504. doi: 10.1016/j.chembiol.2006.03.004. Chem Biol. 2006. PMID: 16720270
Chemical phylogenetics of histone deacetylases.
Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. Bradner JE, et al. Nat Chem Biol. 2010 Mar;6(3):238-243. doi: 10.1038/nchembio.313. Epub 2010 Feb 7. Nat Chem Biol. 2010. PMID: 20139990 Free PMC article.
On the inhibition of histone deacetylase 8.
Estiu G, West N, Mazitschek R, Greenberg E, Bradner JE, Wiest O. Estiu G, et al. Among authors: bradner je. Bioorg Med Chem. 2010 Jun 1;18(11):4103-10. doi: 10.1016/j.bmc.2010.03.080. Epub 2010 Apr 3. Bioorg Med Chem. 2010. PMID: 20472442 Free PMC article.
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Bradner JE, et al. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12617-22. doi: 10.1073/pnas.1006774107. Epub 2010 Jun 28. Proc Natl Acad Sci U S A. 2010. PMID: 20616024 Free PMC article.
261 results