Gopalsamy A - Search Results

1

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Gopalsamy A, et al. J Med Chem. 2006 Jun 1;49(11):3052-5. doi: 10.1021/jm060168g. J Med Chem. 2006. PMID: 16722622

2

Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.

Gopalsamy A, Shi M, Ciszewski G, Park K, Ellingboe JW, Orlowski M, Feld B, Howe AY. Gopalsamy A, et al. Bioorg Med Chem Lett. 2006 May 1;16(9):2532-4. doi: 10.1016/j.bmcl.2006.01.105. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480869

3

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.

Gopalsamy A, Yang H, Ellingboe JW, McKew JC, Tam S, Joseph-McCarthy D, Zhang W, Shen M, Clark JD. Gopalsamy A, et al. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2978-81. doi: 10.1016/j.bmcl.2006.02.067. Epub 2006 Mar 20. Bioorg Med Chem Lett. 2006. PMID: 16545564

4

Discovery of dibenzo[c,f][2,7]naphthyridines as potent and selective 3-phosphoinositide-dependent kinase-1 inhibitors.

Gopalsamy A, Shi M, Boschelli DH, Williamson R, Olland A, Hu Y, Krishnamurthy G, Han X, Arndt K, Guo B. Gopalsamy A, et al. J Med Chem. 2007 Nov 15;50(23):5547-9. doi: 10.1021/jm070851i. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941624

5

Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F. Gopalsamy A, et al. J Med Chem. 2008 Feb 14;51(3):373-5. doi: 10.1021/jm701385c. Epub 2008 Jan 16. J Med Chem. 2008. PMID: 18197612

6

Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (sFRP-1) inhibitors.

Gopalsamy A, Shi M, Stauffer B, Bahat R, Billiard J, Ponce-de-Leon H, Seestaller-Wehr L, Fukayama S, Mangine A, Moran R, Krishnamurthy G, Bodine P. Gopalsamy A, et al. J Med Chem. 2008 Dec 25;51(24):7670-2. doi: 10.1021/jm801069w. J Med Chem. 2008. PMID: 19053830

7

Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.

Park K, Gopalsamy A, Aplasca A, Ellingboe JW, Xu W, Zhang Y, Levin JI. Park K, et al. Among authors: gopalsamy a. Bioorg Med Chem. 2009 Jun 1;17(11):3857-65. doi: 10.1016/j.bmc.2009.04.033. Epub 2009 Apr 22. Bioorg Med Chem. 2009. PMID: 19410464

8

Design and syntheses of 1,6-naphthalene derivatives as selective HCMV protease inhibitors.

Gopalsamy A, Lim K, Ellingboe JW, Mitsner B, Nikitenko A, Upeslacis J, Mansour TS, Olson MW, Bebernitz GA, Grinberg D, Feld B, Moy FJ, O'Connell J. Gopalsamy A, et al. J Med Chem. 2004 Apr 8;47(8):1893-9. doi: 10.1021/jm030540h. J Med Chem. 2004. PMID: 15055990

9

Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1.

Gopalsamy A, Kincaid SL, Ellingboe JW, Groeling TM, Antrilli TM, Krishnamurthy G, Aulabaugh A, Friedrichs GS, Crandall DL. Gopalsamy A, et al. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3477-80. doi: 10.1016/j.bmcl.2004.04.058. Bioorg Med Chem Lett. 2004. PMID: 15177456

10

Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

Gopalsamy A, Lim K, Ellingboe JW, Krishnamurthy G, Orlowski M, Feld B, van Zeijl M, Howe AY. Gopalsamy A, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4221-4. doi: 10.1016/j.bmcl.2004.06.013. Bioorg Med Chem Lett. 2004. PMID: 15261274

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