Gault VA - Search Results

1

Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice.

Green BD, Irwin N, Cassidy RS, Gault VA, Flatt PR. Green BD, et al. Among authors: gault va. Peptides. 2006 Sep;27(9):2343-9. doi: 10.1016/j.peptides.2006.04.008. Epub 2006 May 24. Peptides. 2006. PMID: 16730098

2

Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide.

Gault VA, O'Harte FP, Harriott P, Flatt PR. Gault VA, et al. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1420-6. doi: 10.1006/bbrc.2002.6364. Biochem Biophys Res Commun. 2002. PMID: 11820780

3

Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes.

Gault VA, Flatt PR, Bailey CJ, Harriott P, Greer B, Mooney MH, O'harte FP. Gault VA, et al. Biochem J. 2002 Nov 1;367(Pt 3):913-20. doi: 10.1042/BJ20020319. Biochem J. 2002. PMID: 12150711 Free PMC article.

4

Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP.

O'Harte FP, Gault VA, Parker JC, Harriott P, Mooney MH, Bailey CJ, Flatt PR. O'Harte FP, et al. Among authors: gault va. Diabetologia. 2002 Sep;45(9):1281-91. doi: 10.1007/s00125-002-0894-6. Epub 2002 Jul 16. Diabetologia. 2002. PMID: 12242461

5

Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo.

Gault VA, Parker JC, Harriott P, Flatt PR, O'Harte FP. Gault VA, et al. J Endocrinol. 2002 Nov;175(2):525-33. doi: 10.1677/joe.0.1750525. J Endocrinol. 2002. PMID: 12429050

6

Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide.

Gault VA, Flatt PR, Harriott P, Mooney MH, Bailey CJ, O'Harte FP. Gault VA, et al. J Endocrinol. 2003 Jan;176(1):133-41. doi: 10.1677/joe.0.1760133. J Endocrinol. 2003. PMID: 12525257

7

Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin.

Gault VA, O'Harte FP, Harriott P, Mooney MH, Green BD, Flatt PR. Gault VA, et al. Diabetologia. 2003 Feb;46(2):222-30. doi: 10.1007/s00125-002-1028-x. Epub 2003 Feb 12. Diabetologia. 2003. PMID: 12627321

8

Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide.

Gault VA, Harriott P, Flatt PR, O'Harte FP. Gault VA, et al. Biosci Rep. 2002 Oct-Dec;22(5-6):523-8. doi: 10.1023/a:1022073819618. Biosci Rep. 2002. PMID: 12635849

9

DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser2-Asp13)GIP.

Gault VA, Irwin N, Harriott P, Flatt PR, O'Harte FP. Gault VA, et al. Cell Biol Int. 2003;27(1):41-6. doi: 10.1016/s1065-6995(02)00255-x. Cell Biol Int. 2003. PMID: 12713798

10

Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo.

Gault VA, O'Harte FP, Harriott P, Flatt PR. Gault VA, et al. Metabolism. 2003 Jun;52(6):679-87. doi: 10.1016/s0026-0495(03)00027-1. Metabolism. 2003. PMID: 12800091

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