Irwin N - Search Results

1

Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice.

Green BD, Irwin N, Cassidy RS, Gault VA, Flatt PR. Green BD, et al. Among authors: irwin n. Peptides. 2006 Sep;27(9):2343-9. doi: 10.1016/j.peptides.2006.04.008. Epub 2006 May 24. Peptides. 2006. PMID: 16730098

2

DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser2-Asp13)GIP.

Gault VA, Irwin N, Harriott P, Flatt PR, O'Harte FP. Gault VA, et al. Among authors: irwin n. Cell Biol Int. 2003;27(1):41-6. doi: 10.1016/s1065-6995(02)00255-x. Cell Biol Int. 2003. PMID: 12713798

3

Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo.

Green BD, Gault VA, Mooney MH, Irwin N, Bailey CJ, Harriott P, Greer B, Flatt PR, O'Harte FP. Green BD, et al. Among authors: irwin n. J Mol Endocrinol. 2003 Dec;31(3):529-40. doi: 10.1677/jme.0.0310529. J Mol Endocrinol. 2003. PMID: 14664713

4

Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1.

Green BD, Gault VA, Irwin N, Mooney MH, Bailey CJ, Harriott P, Greer B, Flatt PR, O'Harte FP. Green BD, et al. Among authors: irwin n. Biol Chem. 2003 Dec;384(12):1543-51. doi: 10.1515/BC.2003.171. Biol Chem. 2003. PMID: 14719796

5

Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).

Green BD, Mooney MH, Gault VA, Irwin N, Bailey CJ, Harriott P, Greer B, Flatt PR, O'Harte FP. Green BD, et al. Among authors: irwin n. Metabolism. 2004 Feb;53(2):252-9. doi: 10.1016/j.metabol.2003.09.015. Metabolism. 2004. PMID: 14767880

6

N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.

Green BD, Mooney MH, Gault VA, Irwin N, Bailey CJ, Harriott P, Greer B, O'Harte FP, Flatt PR. Green BD, et al. Among authors: irwin n. J Endocrinol. 2004 Mar;180(3):379-88. doi: 10.1677/joe.0.1800379. J Endocrinol. 2004. PMID: 15012592

7

Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues.

Green BD, Gault VA, Mooney MH, Irwin N, Harriott P, Greer B, Bailey CJ, O'Harte FP, Flatt PR. Green BD, et al. Among authors: irwin n. Biol Chem. 2004 Feb;385(2):169-77. doi: 10.1515/BC.2004.035. Biol Chem. 2004. PMID: 15101559

8

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.

Irwin N, Gault VA, Green BD, Greer B, McCluskey JT, Harriott P, O'Harte FP, Flatt PR. Irwin N, et al. Biol Chem. 2004 Sep;385(9):845-52. doi: 10.1515/BC.2004.110. Biol Chem. 2004. PMID: 15493880

9

Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide.

Irwin N, Green BD, Gault VA, Greer B, Harriott P, Bailey CJ, Flatt PR, O'Harte FP. Irwin N, et al. J Med Chem. 2005 Feb 24;48(4):1244-50. doi: 10.1021/jm049262s. J Med Chem. 2005. PMID: 15715491

10

Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob/ob mice.

Green BD, Irwin N, Gault VA, Bailey CJ, O'Harte FP, Flatt PR. Green BD, et al. Among authors: irwin n. J Endocrinol. 2005 May;185(2):307-17. doi: 10.1677/joe.1.05876. J Endocrinol. 2005. PMID: 15845923

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