Rovnyak G - Search Results

1

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.

Kim KS, Lu S, Cornelius LA, Lombardo LJ, Borzilleri RM, Schroeder GM, Sheng C, Rovnyak G, Crews D, Schmidt RJ, Williams DK, Bhide RS, Traeger SC, McDonnell PA, Mueller L, Sheriff S, Newitt JA, Pudzianowski AT, Yang Z, Wild R, Lee FY, Batorsky R, Ryder JS, Ortega-Nanos M, Shen H, Gottardis M, Roussell DL. Kim KS, et al. Among authors: rovnyak g. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3937-42. doi: 10.1016/j.bmcl.2006.05.037. Epub 2006 May 30. Bioorg Med Chem Lett. 2006. PMID: 16730979

2

Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.

Lombardo LJ, Camuso A, Clark J, Fager K, Gullo-Brown J, Hunt JT, Inigo I, Kan D, Koplowitz B, Lee F, McGlinchey K, Qian L, Ricca C, Rovnyak G, Traeger S, Tokarski J, Williams DK, Wu LI, Zhao Y, Manne V, Bhide RS. Lombardo LJ, et al. Among authors: rovnyak g. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1895-9. doi: 10.1016/j.bmcl.2005.02.004. Bioorg Med Chem Lett. 2005. PMID: 15780629

3

Studies directed toward ascertaining the active conformation of 1,4-dihydropyridine calcium entry blockers.

Rovnyak G, Andersen N, Gougoutas J, Hedberg A, Kimball SD, Malley M, Moreland S, Porubcan M, Pudzianowski A. Rovnyak G, et al. J Med Chem. 1988 May;31(5):936-44. doi: 10.1021/jm00400a008. J Med Chem. 1988. PMID: 2834556

4

Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.

Rovnyak GC, Ahmed SZ, Ding CZ, Dzwonczyk S, Ferrara FN, Humphreys WG, Grover GJ, Santafianos D, Atwal KS, Baird AJ, McLaughlin LG, Normandin DE, Sleph PG, Traeger SC. Rovnyak GC, et al. J Med Chem. 1997 Jan 3;40(1):24-34. doi: 10.1021/jm9605905. J Med Chem. 1997. PMID: 9016325

5

Active conformation of 1,4-dihydropyridine calcium entry blockers. Effect of size of 2-aryl substituent on rotameric equilibria and receptor binding.

Rovnyak G, Andersen N, Gougoutas J, Hedberg A, Kimball SD, Malley M, Moreland S, Porubcan M, Pudzianowski A. Rovnyak G, et al. J Med Chem. 1991 Aug;34(8):2521-4. doi: 10.1021/jm00112a030. J Med Chem. 1991. PMID: 1652021

6

Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.

Krapcho J, Turk C, Cushman DW, Powell JR, DeForrest JM, Spitzmiller ER, Karanewsky DS, Duggan M, Rovnyak G, Schwartz J, et al. Krapcho J, et al. Among authors: rovnyak g. J Med Chem. 1988 Jun;31(6):1148-60. doi: 10.1021/jm00401a014. J Med Chem. 1988. PMID: 2836590

7

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Schwartz J, Moreland S, Hedberg A, Gougoutas JZ, Malley MF, Floyd DM. Atwal KS, et al. Among authors: rovnyak gc. J Med Chem. 1990 May;33(5):1510-5. doi: 10.1021/jm00167a035. J Med Chem. 1990. PMID: 2329573

8

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.

Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, O'Reilly BC, Schwartz J, Malley MF. Rovnyak GC, et al. J Med Chem. 1992 Aug 21;35(17):3254-63. doi: 10.1021/jm00095a023. J Med Chem. 1992. PMID: 1387168

9

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Kimball SD, Floyd DM, Moreland S, Swanson BN, Gougoutas JZ, Schwartz J, Smillie KM, Malley MF. Atwal KS, et al. Among authors: rovnyak gc. J Med Chem. 1990 Sep;33(9):2629-35. doi: 10.1021/jm00171a044. J Med Chem. 1990. PMID: 2391701

10

Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators.

Rovnyak GC, Kimball SD, Beyer B, Cucinotta G, DiMarco JD, Gougoutas J, Hedberg A, Malley M, McCarthy JP, Zhang R, et al. Rovnyak GC, et al. J Med Chem. 1995 Jan 6;38(1):119-29. doi: 10.1021/jm00001a017. J Med Chem. 1995. PMID: 7837222

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