García-Ortega L - Search Results

1

Tyr-48, a conserved residue in ribotoxins, is involved in the RNA-degrading activity of alpha-sarcin.

Alvarez-García E, García-Ortega L, Verdún Y, Bruix M, Martínez del Pozo A, Gavilanes JG. Alvarez-García E, et al. Biol Chem. 2006 May;387(5):535-41. doi: 10.1515/BC.2006.069. Biol Chem. 2006. PMID: 16740124

2

Deletion of the NH2-terminal beta-hairpin of the ribotoxin alpha-sarcin produces a nontoxic but active ribonuclease.

Garcia-Ortega L, Masip M, Mancheño JM, Oñaderra M, Lizarbe MA, García-Mayoral MF, Bruix M, Martínez del Pozo A, Gavilanes JG. Garcia-Ortega L, et al. J Biol Chem. 2002 May 24;277(21):18632-9. doi: 10.1074/jbc.M200922200. Epub 2002 Mar 15. J Biol Chem. 2002. PMID: 11897788 Free article.

3

Leucine 145 of the ribotoxin alpha-sarcin plays a key role for determining the specificity of the ribosome-inactivating activity of the protein.

Masip M, García-Ortega L, Olmo N, García-Mayoral MF, Pérez-Cañadillas JM, Bruix M, Oñaderra M, Martínez del Pozo A, Gavilanes JG. Masip M, et al. Protein Sci. 2003 Jan;12(1):161-9. doi: 10.1110/ps.0225903. Protein Sci. 2003. PMID: 12493839 Free PMC article.

4

NMR structure of the noncytotoxic alpha-sarcin mutant Delta(7-22): the importance of the native conformation of peripheral loops for activity.

García-Mayoral MF, García-Ortega L, Lillo MP, Santoro J, Martínez del Pozo A, Gavilanes JG, Rico M, Bruix M. García-Mayoral MF, et al. Protein Sci. 2004 Apr;13(4):1000-11. doi: 10.1110/ps.03532204. Protein Sci. 2004. PMID: 15044731 Free PMC article.

5

Conserved asparagine residue 54 of alpha-sarcin plays a role in protein stability and enzyme activity.

Siemer A, Masip M, Carreras N, García-Ortega L, Oñaderra M, Bruix M, Del Pozo AM, Gavilanes JG. Siemer A, et al. Biol Chem. 2004 Dec;385(12):1165-70. doi: 10.1515/BC.2004.150. Biol Chem. 2004. PMID: 15653429

6

Modeling the highly specific ribotoxin recognition of ribosomes.

García-Mayoral F, García-Ortega L, Alvarez-García E, Bruix M, Gavilanes JG, del Pozo AM. García-Mayoral F, et al. FEBS Lett. 2005 Dec 19;579(30):6859-64. doi: 10.1016/j.febslet.2005.11.027. Epub 2005 Dec 1. FEBS Lett. 2005. PMID: 16337202 Free article.

7

Fungal ribotoxins: molecular dissection of a family of natural killers.

Lacadena J, Alvarez-García E, Carreras-Sangrà N, Herrero-Galán E, Alegre-Cebollada J, García-Ortega L, Oñaderra M, Gavilanes JG, Martínez del Pozo A. Lacadena J, et al. FEMS Microbiol Rev. 2007 Mar;31(2):212-37. doi: 10.1111/j.1574-6976.2006.00063.x. Epub 2007 Jan 23. FEMS Microbiol Rev. 2007. PMID: 17253975 Free article. Review.

8

The ribonucleolytic activity of the ribotoxin α-sarcin is not essential for in vitro protein biosynthesis inhibition.

Alvarez-García E, Diago-Navarro E, Herrero-Galán E, García-Ortega L, López-Villarejo J, Olmo N, Díaz-Orejas R, Gavilanes JG, Martínez-del-Pozo A. Alvarez-García E, et al. Biochim Biophys Acta. 2011 Oct;1814(10):1377-82. doi: 10.1016/j.bbapap.2011.06.017. Epub 2011 Jul 13. Biochim Biophys Acta. 2011. PMID: 21767671 Free article.

9

Implication of an Asp residue in the ribonucleolytic activity of hirsutellin A reveals new electrostatic interactions at the active site of ribotoxins.

Herrero-Galán E, García-Ortega L, Lacadena J, Martínez-Del-Pozo A, Olmo N, Gavilanes JG, Oñaderra M. Herrero-Galán E, et al. Biochimie. 2012 Feb;94(2):427-33. doi: 10.1016/j.biochi.2011.08.010. Epub 2011 Aug 24. Biochimie. 2012. PMID: 21871524

10

A non-cytotoxic but ribonucleolytically specific ribotoxin variant: implication of tryptophan residues in the cytotoxicity of hirsutellin A.

Herrero-Galán E, García-Ortega L, Lacadena J, Martínez-del-Pozo Á, Olmo N, Gavilanes JG, Oñaderra M. Herrero-Galán E, et al. Biol Chem. 2012 May;393(6):449-56. doi: 10.1515/hsz-2011-0278. Biol Chem. 2012. PMID: 22628308

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