Cooper DG - Search Results

1

Structure-activity studies of pyridinylalkyl-isocytosine H1-receptor antihistamines and identification of an active conformation.

Cooper DG, Durant GJ, Ganellin CR, Ife RJ, Meeson ML, Sach GS. Cooper DG, et al. Farmaco. 1991 Jan;46(1):3-19. Farmaco. 1991. PMID: 1675853

2

Structures of histamine H1-receptor antagonists derived from the cimetidine group of histamine H2-receptor antagonists.

Bannister C, Burns K, Prout K, Watkin DJ, Cooper DG, Duránt GJ, Ganellin CR, Ife RJ, Sach GS. Bannister C, et al. Among authors: cooper dg. Acta Crystallogr B. 1994 Apr 1;50 ( Pt 2):221-43. doi: 10.1107/s0108768193010407. Acta Crystallogr B. 1994. PMID: 7911673

3

Icotidine, an antagonist of histamine at both H1 and H2 receptors.

Ganellin CR, Blakemore RC, Brown TH, Cooper DG, Durant GJ, Harvey CA, Ife RJ, Owen DA, Parsons ME, Rasmussen AC, et al. Ganellin CR, et al. Among authors: cooper dg. N Engl Reg Allergy Proc. 1986 Mar-Apr;7(2):126-33. doi: 10.2500/108854186779047762. N Engl Reg Allergy Proc. 1986. PMID: 2886901

4

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.

Forbes IT, Cooper DG, Dodds EK, Hickey DM, Ife RJ, Meeson M, Stockley M, Berkhout TA, Gohil J, Groot PH, Moores K. Forbes IT, et al. Among authors: cooper dg. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1803-6. doi: 10.1016/s0960-894x(00)00347-4. Bioorg Med Chem Lett. 2000. PMID: 10969972

5

Identification of a novel series of selective 5-HT7 receptor antagonists.

Forbes IT, Cooper DG, Dodds EK, Douglas SE, Gribble AD, Ife RJ, Lightfoot AP, Meeson M, Campbell LP, Coleman T, Riley GJ, Thomas DR. Forbes IT, et al. Among authors: cooper dg. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1055-8. doi: 10.1016/s0960-894x(03)00077-5. Bioorg Med Chem Lett. 2003. PMID: 12643910

6

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.

Witherington J, Bordas V, Cooper DG, Forbes IT, Gribble AD, Ife RJ, Berkhout T, Gohil J, Groot PH. Witherington J, et al. Among authors: cooper dg. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2177-80. doi: 10.1016/s0960-894x(01)00397-3. Bioorg Med Chem Lett. 2001. PMID: 11514164

7

Studies towards the identification of a new generation of atypical antipsychotic agents.

Garzya V, Forbes IT, Gribble AD, Hadley MS, Lightfoot AP, Payne AH, Smith AB, Douglas SE, Cooper DG, Stansfield IG, Meeson M, Dodds EE, Jones DN, Wood M, Reavill C, Scorer CA, Worby A, Riley G, Eddershaw P, Ioannou C, Donati D, Hagan JJ, Ratti EA. Garzya V, et al. Among authors: cooper dg. Bioorg Med Chem Lett. 2007 Jan 15;17(2):400-5. doi: 10.1016/j.bmcl.2006.10.036. Epub 2006 Oct 19. Bioorg Med Chem Lett. 2007. PMID: 17084080

8

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.

Berkhout TA, Blaney FE, Bridges AM, Cooper DG, Forbes IT, Gribble AD, Groot PH, Hardy A, Ife RJ, Kaur R, Moores KE, Shillito H, Willetts J, Witherington J. Berkhout TA, et al. Among authors: cooper dg. J Med Chem. 2003 Sep 11;46(19):4070-86. doi: 10.1021/jm030862l. J Med Chem. 2003. PMID: 12954060

9

Primate vascular responses to octimibate, a non-prostanoid agonist at the prostacyclin receptor.

Merritt JE, Brown AM, Bund S, Cooper DG, Egan JW, Hallam TJ, Heagerty AM, Hickey DM, Kaumann AJ, Keen M, et al. Merritt JE, et al. Among authors: cooper dg. Br J Pharmacol. 1991 Jan;102(1):260-6. doi: 10.1111/j.1476-5381.1991.tb12163.x. Br J Pharmacol. 1991. PMID: 2043927 Free PMC article.

10

Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor.

Merritt JE, Hallam TJ, Brown AM, Boyfield I, Cooper DG, Hickey DM, Jaxa-Chamiec AA, Kaumann AJ, Keen M, Kelly E, et al. Merritt JE, et al. Among authors: cooper dg. Br J Pharmacol. 1991 Jan;102(1):251-9. doi: 10.1111/j.1476-5381.1991.tb12162.x. Br J Pharmacol. 1991. PMID: 1710526 Free PMC article.

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