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EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.
Arif A, Terenzi F, Potdar AA, Jia J, Sacks J, China A, Halawani D, Vasu K, Li X, Brown JM, Chen J, Kozma SC, Thomas G, Fox PL. Arif A, et al. Among authors: kozma sc. Nature. 2017 Feb 16;542(7641):357-361. doi: 10.1038/nature21380. Epub 2017 Feb 8. Nature. 2017. PMID: 28178239 Free PMC article.
S6K1 deficiency protects against apoptosis in hepatocytes.
González-Rodriguez A, Alba J, Zimmerman V, Kozma SC, Valverde AM. González-Rodriguez A, et al. Among authors: kozma sc. Hepatology. 2009 Jul;50(1):216-29. doi: 10.1002/hep.22915. Hepatology. 2009. PMID: 19437488 Free PMC article.
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Thomas G. Pende M, et al. Among authors: kozma sc. Mol Cell Biol. 2004 Apr;24(8):3112-24. doi: 10.1128/MCB.24.8.3112-3124.2004. Mol Cell Biol. 2004. PMID: 15060135 Free PMC article.
S6K1 controls pancreatic β cell size independently of intrauterine growth restriction.
Um SH, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tschöp MH, Thomas G, Kozma SC. Um SH, et al. Among authors: kozma sc. J Clin Invest. 2015 Jul 1;125(7):2736-47. doi: 10.1172/JCI77030. Epub 2015 Jun 15. J Clin Invest. 2015. PMID: 26075820 Free PMC article.
84 results